Publications by authors named "Judith Chekwube Duhu"
Potential enhancement of metformin hydrochloride in solidified reverse micellar solution-based PEGylated lipid nanoparticles targeting therapeutic efficacy in diabetes treatment.
Franklin Chimaobi Kenechukwu Daniel Okwudili Nnamani Judith Chekwube Duhu Bright Ugochukwu Nmesirionye Mumuni Audu Momoh
Heliyon
March 2022
Article Synopsis
- Metformin hydrochloride (MH) is an effective but poorly absorbed diabetes medication, prompting researchers to create PEGylated solid lipid nanoparticles (PEG-SLNs) to enhance its delivery and effectiveness.
- This study involved formulating and characterizing these nanoparticles by using specific lipid matrices and various methodologies, including high shear hot homogenization and multiple characterization techniques like DSC and FT-IR spectroscopy.
- The results showed that PEG-SLNs had a smooth, spherical shape and favorable properties, such as an encapsulation efficiency and improved performance in antidiabetic studies on rats when compared to standard MH formulations.