Publications by authors named "Judith Caroline Ngo Nyobe"

The chemical investigation of the methanolic root extract of (P. Beauv.) Gilg exhibited two new 30-norfriedelane triterpenes, glaucalactones A and B (), together with eight known compounds, caloncobalactone (), friedelin (), friedelanol ), 3-oxo-friedelan-28-oic acid (), stigmasterol (), -sitosterol (), -sitosterol-3---D-glucopyranoside () and pentacosanoic acid ().

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Article Synopsis
  • A study on the roots of Macfad (Rutaceae) identified two new compounds, 1-formyl-5-hydroxy--methylindolin-1-ium and decyloxycleomiscosin D, along with ten known compounds that were analyzed using advanced spectroscopic techniques.
  • The structures of the new compounds were established through 1D and 2D NMR, EI- and ESI-MS, and comparisons with existing literature, marking their first identification in this genus.
  • The methanol extract of the roots and the compounds were tested against cancer cell lines (A549 and PC3), showing the extract had significant anti-cancer activity, while the individual compounds displayed weaker effects.
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A chemical investigation of the leaves of Stapf. led to the isolation of a new phenylpropanol derivative, namely irisdichototin G (), together with nine known compounds, including one polyol derivative, dambonitol (); three alkaloids, 10-hydroxycoronaridine (), voacristine () and vobasine (); two triterpenes lupeol (), betulinic acid () and three sterols, sitosterol (), sitosterol-3-O-β-D-glucopyranoside () and stigmasterol (). The structure of the new compound, as well as those of the known ones, was established by means of spectroscopic methods: NMR analysis ( and C NMR, 1H-1H-COSY, HSQC, HMBC and NOESY), high-resolution mass spectrometry (HR-ESI-MS) and comparisons with previously reported data.

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Fractionation of the methanol extract of the leaves of Oricia renieri and Oricia suaveolens (Rutaceae) led to the isolation of 13 compounds including the hitherto unknown furoquinoline alkaloid named 6,7-methylenedioxy-5-hydroxy-8-methoxy-dictamnine (1) and a flavanone glycoside named 5-hydroxy-4'-methoxy-7-O-[α-L-rhamnopyranosyl(1‴→5″)-β-D-apiofuranosyl]-flavanoside (2), together with 11 known compounds (3-13). The structures of the compounds were determined by comprehensive analyses of their 1D and 2D NMR, mass spectral data and comparison. All compounds isolated were examined for their activity against human carcinoma cell lines.

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