Aim: Obinutuzumab induces NK cell antibody-dependent cell-mediated cytotoxicity.
Objective: Investigate the effects on the human immune system after obinutuzumab monotherapy treatment in patients with chronic lymphocytic leukemia (CLL).
Method: To evaluate these effects, we analyzed the distribution of CD4 and CD8 T cells, B cells and NK cells in the peripheral blood of eight CLL patients who were treated with obinutuzumab in monotherapy.