Publications by authors named "Judiann W DeLan"
Morphological score assignment guidelines for the dechorionated zebrafish teratogenicity assay.
Birth Defects Res B Dev Reprod Toxicol
October 2010
Article Synopsis
- Developed a zebrafish teratogenicity assay that accurately identifies teratogens with 87% concordance, using dechorionated AB strain embryos.
- The assay employs a morphological scoring system to assess adverse effects and determine the no-observed-adverse-effect level (NOAEL).
- The scoring system evaluates various structures and organ systems, providing insights into tissue-specific teratogenicity and allowing for ranking of compounds based on the severity of malformations.