Comparative effects of adrenal regeneration hypertension on non-arteriosclerotic and arteriosclerotic Sprague-Dawley vs spontaneously hypertensive rats.

Adrenal regeneration hypertension (ARH) was induced in virgin and breeder, spontaneously hypertensive (SHR) and Sprague-Dawley (SD) rats. The blood pressure of the previously normotensive, virgin, SD rats and the SD breeder rats with preexistent mild hypertension became greatly elevated. ARH caused an increase in the preexisted severe hypertension in SHR virgin and breeder rats.

Aortic prolyl hydroxylase and the development of arteriosclerosis in the female breeder rat.

Female breeder rats develop arteriosclerosis spontaneously. The primary lesions seen in the early stages of the disease consist of subintimal and adjacent medial ground substance accumulations. With repeated breeding there is extensive elastolysis and calcification in the aorta.

Arterial lesions in repeatedly bred spontaneously hypertensive rats.

Repeatedly bred male and female rats of many strains develop hyperglycemia, hyperlipidemia, hypertension, and arteriosclerosis spontaneously. The intensity of their arterial disease and related metabolic derangements appear to be related to their reproductive activity. Repeatedly bred spontaneously hypertensive rats (SHR) were found to have severe hypertension, hyperglycemia, hyperlipidemia, elevated creatine phosphokinase (CPK), serum glutamic oxaloacetic and glutamic pyruvic transaminase (SGOT, SGPT), and lactic dehydrogenase (LDH), as well as high circulating corticosterone levels.

Changing risks in tuberculosis.

Past and present experience with tuberculosis in New York State exclusive of New York City is presented. TB has been on the decline since the turn of the century and reached an all-time low in 1974 with only 844 new active cases and 137 deaths reported. Although incidence rates are highest among the poor, the bulk of cases come from middle and upper socioeconomic levels.

Mechanized blood grouping: a hospital trial using an 8-channel grouping machine.

ABO and Rh (D) groups of 6403 blood samples were assessed on an 8/9-channel autoanalyser in the Serology Department of the London Hospital; the results were independently checked at the Regional Blood Transfusion Centre, Brentwood, using the routine methods for grouping donor blood. Results of this comparative study are given and instances are described in which anomalous results or incorrect groupings occurred; the possible causes are discussed. The 8/9-channel automated blood group analyser is evaluated in terms of routine hospital laboratory practice.

Aortic hexosamine, [35S]sulfate uptake, and calcium metabolism related to early arterial degenerative changes induced by lactation and forced weaning in breeder rats.

The relation of lactation and weaning to the development of early arterial lesions in the female breeder rat was investigated. Changes in aortic hexosamine and 35S-uptake, which are indicative of ground substance metabolism were correlated with changes in aortic calcium, phosphorus, and 45Ca-uptake during lactation and weaning. Lactation was associated with reduced aortic hexosamine content and lowered uptake of [S]sulfate.

Prolyl hydroxylase and collagen metabolism after experimental mycardial infarction.

Mature male Sprague-Dawley rats were subjected to an isoproterenol-induced myocardial infarction. Animals were sacrificed on a daily basis in order to assess the temporal changes in prolyl hydroxylase activity and collagen metabolism during the acute stages of myocardial necrosis and repair. Total myocardial hydroxyproline, as an indexof collagen content, increased promptly and markedly, beginning on day 4, and remained elevated thereafter.

Metabolic and histopathological consequences of a fatty liver during the acute stages of myocardial infarction in rats.

Adult, male Sprague-Dawley rats were fed a regular rat chow diet or a diet containing 1 per cent orotic acid. Ten days later, orotic acid fed animals had severe, fatty metamorphosis of the liver. Both the regular diet animals and the orotic acid fed animals were given 2, daily, s.

Late pleistocene paleotemperatures at tongue of the ocean, bahamas.

Estimates of paleotemperatures, based upon paleoecological analysis of planktonic foraminiferal thanatocoenoses of three piston cores from Tongue of the Ocean, Bahamas, indicate a maximum mean variation between Late Pleistocene glacial and nonglacial stages of 3.6 degrees C. The data also indicate that the Early Wisconsin glacial stage was 0.

Acute myocardial histopathology in normal and arteriosclerotic rats during isoproterenol-induced infarction.

Arteriosclerotic and non-arteriosclerotic, male Sprague-Dawley rats were given 2 s.c. injections of isoproterenol known to produce extensive myocardial infarction.