Deep Learning Application to Detect Glaucoma with a Mixed Training Approach: Public Database and Expert-Labeled Glaucoma Population.

Introduction: Artificial intelligence has real potential for early identification of ocular diseases such as glaucoma. An important challenge is the requirement for large databases properly selected, which are not easily obtained. We used a relatively original strategy: a glaucoma recognition algorithm trained with fundus images from public databases and then tested and retrained with a carefully selected patient database.

Polymorphisms in gene and the risk of suffering Primary Open-Angle Glaucoma: Systematic review and meta-analysis.

Purpose: It had been reported that mutations in gene probably play an important role in the pathogenesis of primary open angle glaucoma (POAG) but the existing genetic association studies show contradictory results. Thus, the objective of our study was to perform a systematic review and meta-analysis to characterize more precisely the potential association between given polymorphisms in gene and the risk of suffering POAG.

Methods: A systematic review of studies that related the risk of carrying gene polymorphisms with POAG development was conducted.

Management and Systemic Implications of Diabetic Neovascular Glaucoma.

Objectives: To study the efficacy and safety of different treatments for diabetic neovascular glaucoma (NVG). We additionally attempt to determine if the presence of NVG could be a predictor of cardiovascular disease or death.

Method: This is a retrospective, observational cohort study including patients diagnosed with diabetic NVG from 2006 to 2016 at the Hospital Clínico Universitario de Valladolid (Spain).

Association between SNPs of Metalloproteinases and Prostaglandin F2α Receptor Genes and Latanoprost Response in Open-Angle Glaucoma.

Purpose: To determine whether single nucleotide polymorphisms (SNPs) of genes coding for matrix metalloproteinases (MMPs) and the prostaglandin F2α receptor gene (PTGFR) are related to a response to latanoprost in a white Spanish population of glaucomatous patients.

Design: Case-control study.

Participants: One hundred twenty-four patients with open-angle glaucoma.

[Ocular loiasis in a patient with chronic hypereosinophilia].

Case Report: We present a case of ocular loiasis with a subconjunctival filaria, 5.5cm long, and a severe microfilaremia, 1 microfilaria/ml, on a previously asymptomatic woman from Equatorial Guinea, with a past medical history of hypereosinophilia of unknown origin.

Discussion: Ocular loiasis is an imported infestation with a very low rate in our country.

Can we measure mesopic pupil size with the cobalt blue light slit-lamp biomicroscopy method?

Background: The aim of this work is to assess a previously described slit-lamp biomicroscopy-based method (SLBM) for measuring pupil diameter and compare it to Colvard infrared pupillometry (CIP).

Methods: Two examiners performed three repeated measurements with each instrument in 40 healthy eyes. We determined the agreement of SLBM and CIP, intraobserver and interobserver repeatabilities, and interobserver concordance (kappa) and SLBM ability for detecting pupil sizes over 6.

[Decompression retinopathy with maculopathy after trabeculectomy with mitomycin C].

Case Report: We present a case of decompression retinopathy with retinal haemorrhages, optic nerve haemorrhages, maculopathy, and decreased visual acuity after trabeculectomy with mitomycin-C.

Discussion: Decompression retinopathy is a potential complication after glaucoma surgery but has been rarely reported in the world literature. Although these four characteristics have been described separately, in this patient all four occurred together.

Flap tearing during lift-flap laser in situ keratomileusis retreatment.

A flap tear occurred during laser in situ keratomileusis (LASIK) retreatment using a flap-lifting technique in 1 eye of 2 patients 4 to 5 months after the primary procedure. In the first case, the tear occurred in a decentered, standard thickness flap (168 mum) in a location close to the corneal limbus and limbal vessels. In the second case, the tear occurred in a well-centered thin flap (116 mum) that involved a peripheral corneal pannus.

Subtarsal flap dislocation after superior hinge laser in situ keratomileusis in a patient with borderline mental illness.

Purpose: To report a case of complete subtarsal flap dislocation after uncomplicated superior hinge laser in situ keratomileusis (LASIK).

Methods: Flap dislodgement resulted from eye rubbing in a patient with a past medical history of mental illness and epilepsy. The dislocated cap, which was also folded in half, was refloated, profusely irrigated, and ironed to eliminate flap wrinkles.

Extensive corneal epithelial defect associated with internal hordeolum after uneventful laser in situ keratomileusis.

This report illustrates a retrospective case review in which extensive corneal epithelial ulceration occurred concomitantly with an internal hordeolum in the inferior forniceal conjunctiva 24 hours after an uneventful laser in situ keratomileusis. The internal hordeolum and epithelial defect were successfully managed using a bandage soft contact lens, a course of topical dexamethasone and tobramycin, and generous lubrication.

Efficacy of topical cyclosporine-loaded nanocapsules on keratoplasty rejection in the rat.

Purpose: To evaluate the efficacy of a topical formulation of nanocapsules loaded with 1% cyclosporine A (CsA), which has been previously demonstrated to enhance CsA corneal penetration, compared to 1% CsA in migliol oil on a penetrating keratoplasty rejection model in the rat.

Methods: Lewis rats received orthotopic corneal allografts from inbred Fisher donors. Rats were treated with 10 microliters of the following topical solutions four times daily for 30 days, starting one day before surgery: Group 1 (n = 9), 1% CsA-loaded nanocapsules; group 2 (n = 13), 1% CsA dissolved in migliol oil; group 3 (n = 12), migliol oil; group 4 (n = 13), no treatment.

Phlyctenular keratoconjunctivitis a potentially blinding disorder.

Phlyctenular keratoconjunctivitis, a delayed hypersensitivity reaction to foreign proteins (i.e., bacterial products), occurs more often in children and young adults sensitized to Staphylococcus aureus inhabiting the lid margins.