Publications by authors named "Juanying Wu"
Background: Metabolic syndrome (MS) is characterized by a constellation of metabolic disorders. Hyperglycemia and dyslipidemia are the major risk factors of MS. Here we performed a study to explore the association between glycated hemoglobin A1c (HbA1c) and high-density lipoprotein (HDL) subclasses in patients with MS.
View Article and Find Full Text PDFWe aimed to investigate whether a combination of resistance to arsenic trioxide (As2O3) and the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway inhibitor LY294002 can inhibit the proliferation of AML cells in the bone marrow microenvironment. Three AML cell lines were grown with HS-5 human bone marrow stromal cells in adherent co-cultures. The inhibitory effects of As2O3 alone or in combination with LY294002 on the proliferation of these co-cultured AML cells were observed.
View Article and Find Full Text PDF[Expression of HIF-1α in primary acute myeloid leukemia cells and its relationship with prognosis].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
February 2015
Article Synopsis
- - This study investigated the role of HIF-1α expression in acute myeloid leukemia (AML) and its correlation with clinical outcomes, examining samples from 53 newly diagnosed patients.
- - Results showed that HIF-1α levels did not significantly relate to age, sex, or other standard clinical factors, but higher expression was noted in patients who did not achieve complete remission and had a higher relapse rate.
- - The findings suggest that elevated HIF-1α is associated with extramedullary infiltration in AML and could serve as an early indicator of poor prognosis in these patients.
The anti-CD44 monoclonal antibody (mAb) A3D8 induces differentiation or apoptosis in vitro in various subtypes of acute myeloid leukemia (AML) via p27(Kip1) upregulation. Bone marrow (BM) stromal cells play a vital role in the development of chemoresistance in AML cells attached to the stroma. To investigate the effect of BM stroma adhesion induced AML resistance to A3D8, we developed a co-culture system composed of an AML-derived cell line (NB4) cultured with either a human BM stroma cell line (HS-5) or mesenchymal stem cells (MSCs).
View Article and Find Full Text PDFAll-trans retinoic acid (ATRA) and arsenic trioxide (As2O3) are the classic drugs used for induction therapy of acute promyelocytic leukemia (APL). IL-3Ralpha (CD123) is a specific marker of acute myeloid leukemia stem cells (AML-LSCs). The over-expression of IL-3Ralpha in patients with AML is related to high white blood cells counts, high percentages of blast cells, and poor prognosis.
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