Combining multi-dimensional molecular fingerprints to predict the hERG cardiotoxicity of compounds.

Recently, drug toxicity has become a critical problem with heavy medical and economic burdens. Acquired long QT syndrome (acLQTS) is an acquired cardiac ion channel disease caused by drugs blocking the hERG channel. Therefore, it is necessary to avoid cardiotoxicity in drug design, and computer models have been widely used to fix this predicament.

The tainted altruism effect: a successful pre-registered replication.

Newman and Cain (Newman, Cain 2014 , 648-655 (doi:10.1177/0956797613504785)) reported that observers view a person's choices as less ethical when that person has acted in response to both altruistic and selfish (commercial) motivations, as compared with purely selfish interests. The altruistic component reduces the observers' approval rather than raising it.

Prenatal ultrasound-assisted identification of multiple malformations caused by a deletion in the long-arm end of chromosome 7 and review of the literature.

Clinical cases of chromosome 7 long-arm end deletion are rare. Generally, 7q terminal deletion syndrome results in complex clinical phenotypes, such as microcephaly, growth and development retardation, holoprosencephaly, and sacral hypoplasia. Herein, we report the genetic and clinical features of a fetus with multiple malformations observed by prenatal ultrasound.