miRNA targeting Mpp53 is involved in UV-B irradiation resistance in Myzus persicae.

Ultraviolet (UV) radiation, an environmental stressor, is crucial for the survival and adaptation of organisms. Myzus persicae, a global pest, is exposed to sunlight year-round, making it unable to avoid UV rays in its environment. MicroRNAs (miRNAs) are important posttranscriptional regulators of gene expression and mediate various biological processes.

Rare-Metal-Free Ultrabroadband Near-Infrared Phosphors.

Trivalent chromium (Cr) is an attractive near-infrared (NIR) emitter, but its ultrabroadband NIR emission is limited to host crystals containing large amounts of rare-metal elements and usually suffers from low internal quantum efficiency (IQE) and poor thermal stability. Here, a class of high-performance, rare-metal-free ultrabroadband NIR phosphors, are reported by revealing that weak-field Cr centers featuring broadband NIR emission with near-unity IQEs are intrinsic, though in trace quantities, to Cr doped MgAlO spinel (MAS) and its derivatives well-known for their narrowband far-red emission. It is shown that such weak-field Cr centers stem from cation inversion ubiquitous in spinel compounds, and their quantity can be increased simply by superstoichiometric AlO/GaO.

Operando Studies Redirect Spatiotemporal Restructuration of Model Coordinated Oxides in Electrochemical Oxidation.

Tetrahedral, pyramidal, and octahedral metal-oxygen coordinated ligands are fundamental components in all metal-oxide structures. Understanding the impacts of their spatiotemporal behaviors during electrochemical oxidation is crucial for diverse applications, yet remains unsolved due to challenges in designing model oxides and conducting operando characterizations. Herein, combining a suite of advanced operando characterizations and systematic computations, a link between oxygen-evolving performance and operational structural properties is established on model oxides.

High-Performance Broad-Spectrum UV Photodetectors with Uniform Response: Engineering β-GaO:Si/GaN:Si Heterojunctions via Thermal Oxidation for Optoelectronic Logic Gate and Multispectral Imaging.

Developing high-performance, broad-spectrum ultraviolet photodetectors (PDs) with uniform response is crucial for optoelectronic applications like spectral analysis, optoelectronic logic gates, and multispectral imaging. This study constructs n-n type β-GaO:Si/GaN:Si heterojunction PDs using thermal oxidation, combining the advantages of β-GaO:Si and GaN:Si for excellent broad-spectrum response (UV-A to UV-C). A proposed channel model for GaN:Si oxidation includes hole formation, vortex structure development, channel formation, and grain growth, providing a basis for understanding β-GaO:Si/GaN:Si heterojunction formation.

Lrp Family Regulator SCAB_Lrp2 Responds to the Precursor Tryptophan and Represses the Thaxtomin Biosynthesis in Streptomyces scabies.

Streptomyces scabies is a well-researched plant pathogen belonging to the genus Streptomyces. Its virulence is linked to the production of the secondary metabolite thaxtomin A, which is tightly regulated at the transcriptional level. The leucine-responsive regulatory protein (Lrp) family is conserved in prokaryotes and is involved in various crucial biological processes.

The roles of lactate and the interplay with mA modification in diseases.

Lactate exhibits various biological functions, including the mediation of histone and non-histone lactylation to regulate gene transcription, influencing the activity of T lymphocytes, NK cells, and macrophages in immune suppression, activating G protein-coupled receptor 81 for signal transduction, and serving as an energy substrate. The mA modification represents the most prevalent post-transcriptional epigenetic alteration. It is regulated by mA-related regulatory enzymes (including methyltransferases, demethylases, and recognition proteins) that control the transcription, splicing, stability, and translation of downstream target RNAs.

IL33-induced neutrophil extracellular traps (NETs) mediate a positive feedback loop for synovial inflammation and NET amplification in rheumatoid arthritis.

This study investigated the mechanisms driving the induction and sustained presence of neutrophil extracellular traps (NETs) in the synovial microenvironment of rheumatoid arthritis (RA). Synovial tissue and fluid samples were collected from patients with RA and osteoarthritis (OA), and NET levels and cytokine concentrations were measured using a cytometric bead array and enzyme-linked immunosorbent assay (ELISA). The ability of interleukin-33 (IL-33) to induce NET formation was evaluated using quantitative assays, immunofluorescence staining, live-cell imaging, and electron microscopy.

Genome‑wide identifcation and expression analysis of growth-regulating factors under drought in Brassica juncea.

Growth-regulating factors (GRFs) are plant-specific transcription factors involved in the regulation of plant growth, development, and abiotic stress processes. However, the function of Brassica juncea (L.) Czern & Coss GRFs remain largely unknown.

Building Block for Designing Bright Type I AIE-Active Photosensitizers with Deep/Near-infrared Red Fluorescence.

Bright deep red/near-infrared red (DR/NIR) active type I photosensitizers (PSs) with generating superoxide anion and hydroxyl radical have been regarded as powerful functional materials to fight the "Achilles's heel" of hypoxia from solid tumor. But some problems have still existed, for example, lacking effective molecular designed strategy or typical building block to design precisely type I PSs. In addition, the relationship between fluorescent quantum efficiency and NIR fluorescent color is inconsistent according to energy gap rule.

BMSMM-Net: A Bone Metastasis Segmentation Framework Based on Mamba and Multiperspective Extraction.

Rationale And Objectives: Metastatic bone tumors significantly reduce patients' quality of life and expedite cancer spread. Traditional diagnostic methods rely on time-consuming manual annotations by radiologists, which are prone to subjectivity. Employing deep learning for rapid, precise segmentation of bone metastases can greatly improve patient outcomes and survival.

Examining the effects of moral distress, compassion fatigue and burnout on intention to leave among nursing students in Hong Kong: A cross-sectional study.

Background: Compassion fatigue and burnout have detrimental effects on nursing students. Moral distress has been recognized as a contributing factor to both, potentially impacting the intention to leave nursing programme.

Aim: To examine relationships among moral distress, compassion fatigue and burnout on intention to leave the nursing programme among nursing students.

Plasmid-mediated transfer of antibiotic resistance genes and biofilm formation in a simulated drinking water distribution system under chlorine pressure.

The effects of disinfectants and plasmid-based antibiotic resistance genes (ARGs) on the growth of microorganisms and the plasmid-mediated transfer of ARGs in the water and biofilm of the drinking water distribution system under simulated conditions were explored. The heterotrophic plate count of the water in reactors with 0.1 mg/L NaClO and NHCl was higher than in the control groups.

Biodegradation-assisted removal of sulfur-based odor compounds in rural drinking water using durable chitosan/polyvinyl alcohol biochar aerogels.

Rural drinking water often suffers from unpleasant odors like dimethyl sulfide (DMDS) and dimethyl trisulfide (DMTS) due to poor raw water quality and limited treatment options. This study introduces durable chitosan/polyvinyl alcohol (PVA) biochar aerogels-supported bioflims in ultrafiltration (BAB-UF) reactors, where the incorporation of PVA significantly enhances structural integrity, biodegradation resistance, and functional lifespan, providing an efficient, sustainable solution for removing odorous compounds from rural water. Experimental results showed the enhanced chitosan/PVA porous biochar aerogels (CPPCA) displayed excellent biocapacity and structural stability.

Therapeutic potential of interleukin-17 neutralization in a novel humanized mouse model of Sjögren's disease.

Sjögren's disease (SjD) is a chronic autoimmune disease, in which the immune system targets exocrine glands and leads to dryness symptoms. There is an increasing need to develop novel therapeutic approach as the treatment plan has not been changed in the past decade. However, findings in mouse model may not be directly applied in patients, given the substantial differences of immune system between human and mice.

A novel type III effector RipBU from Ralstonia solanacearum suppresses plant immunity and promotes peanut susceptibility.

A predicted peanut R. solanacearum T3E RS_T3E_Hyp6 was identified as a definite T3E and renamed as RipBU. It is relative conserved in 31 R.

SMURF1 leads to the β-catenin signaling-mediated progression of esophageal squamous carcinoma by losing PATZ1-induced CCNG2 transcription.

Cyclin G2 (CCNG2), a known inhibitor of cell cycle progression, has been identified as a suppressor for the canonical β-catenin pathway. This study explores the impact of CCNG2 on β-catenin activity and malignant characteristics of esophageal squamous cell carcinoma (ESCC) cells, and the mechanism behind CCNG2 dysregulation. In ESCC tissues and cells, CCNG2 was under-expressed and associated with poor clinical outcomes, whereas β-catenin showed an opposite trend.

Retinopathy in Parkinson's disease: A potential biomarker for early diagnosis and clinical assessment.

Parkinson's disease (PD) is a prevalent neurodegenerative disorder caused by degeneration of dopaminergic neurons, originating from the substantia nigra pars compacta, and characterized by motor symptoms such as bradykinesia, muscle rigidity, resting tremor, and postural instability, as well as non-motor symptoms such as anxiety, depression, reduced sense of smell, cognitive impairment, and visual dysfunction. Emerging evidence highlights the retina as a promising site for non-invasive exploration of PD pathology, due to its shared embryonic origin with the central nervous system. In recent years, with the development of ophthalmic technology, the acquisition of retinal-related function and structure has gradually become mature.

Integrated proteomic and metabolomic analysis reveals the potential therapeutic mechanism of Quanduzhong capsule in rats with spontaneous hypertension and knee osteoarthritis.

Ethnopharmacological Relevance: Quanduzhong capsule (QDZ), derived from Eucommia ulmoides Oliv., has been traditionally used in Chinese medicine for its beneficial effects on musculoskeletal health. Its clinical application has extended to conditions such as spontaneous hypertension combined with knee osteoarthritis (SKOA).

Anti-rheumatic arthritis efficacy of Pueraria montana extract against type-II collagen-induced rheumatoid arthritis rat model an in vitro and in vivo assessment.

Ethnopharmacological Relevance: Pueraria montana (PM) is a Chinese medicinal herb used to treat alcoholism, inflammation, swelling, and anti-apoptosis. However, the mechanisms and active compounds of PM remain poorly understood.

Aim Of The Study: Chronic inflammatory diseases such as rheumatoid arthritis (RA) can affect multiple joints.

Serum metabolomics and 16S rRNA amplicon sequencing reveal the role of puerarin in alleviating bone loss aggravated by antidiabetic agent pioglitazone in type 2 diabetic mice.

Ethnopharmacological Relevance: Pioglitazone (PIO) was an anti type 2 diabetes (T2D) agent but caused bone loss and bone marrow fat accumulation. Puerarin (PUE) was a natural component of herbal medicine extracted from Pueraria lobata (Willd.) Ohwi and reduced glycemia and improved bone mass as a supplementary drug.

Association between the Life's essential 8 health behaviors score and all-cause mortality in patients with metabolic dysfunction-associated steatotic liver disease.

Background: The association between Life's Essential 8 (LE8) score and all-cause mortality in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) remains unknown.

Methods: This population-based prospective cohort study analyzed data of participants aged 20-79 years in the National Health and Nutrition Examination Survey from 2005 to 2018, with linked mortality information until 2019. Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for the association between different cardiovascular health (CVH) scores and all-cause mortality in participants with MASLD.

Arenobufagin Induces Ferroptosis in Glioblastoma Cells via Modulating the MiR-149-5p/AEBP1 Axis.

Accumulating evidences have proved Arenobufagin (ArBu) exhibited cytotoxic effects to multiple types of cancer. However, in glwioblastoma (GBM), which is easy to develop resistance to classic chemotherapy reagent, the therapeutic effects of ArBu have not been explored. In the current study, we found that GBM cells were sensitive to ArBu treatment and ArBu induced cell death both in a dose-dependent and a time-dependent manner.