The Substitution of Rare-Earth Gd in BaScCuTe Realizing the Band Degeneracy and the Point-Defect Scattering toward Enhanced Thermoelectric Performance.

Zintl compounds have continuously received significant attention, primarily due to their structural characteristics that align with the properties of the electron crystal and phonon glass. In this study, the crystal structure and thermoelectric properties of the quaternary Zintl chalcogenide BaScCuTe are investigated. The band structure calculations for BaScCuTe reveal a slight energy split of 0.

Tandem mass tag-based serum proteomic profiling revealed diabetic foot ulcer pathogenesis and potential therapeutic targets.

Diabetic foot ulcer (DFU), one of the most serious complications of diabetes mellitus, is associated with a high amputation rate and decreased life quality. The impact of blood serum proteins on the occurrence and development of DFU has attracted a lot of interest. In this study, we aimed to define and compare the serum proteome of patients with DFU and healthy control (HC) to provide new insights into DFU pathogenesis.

Improved Thermal Stability and Enhanced Thermoelectric Properties of p-Type BaCuTe by Doping of Cl.

Doping in semiconductors is a widely implemented strategy for manipulation of carrier concentration, which is a critical parameter to regulate the thermoelectric performance. Stoichiometric BaCuTe shows high hole concentration and unstable transport properties owing to the inherent Cu vacancy and dynamic precipitation behavior. In this work, Te has been partially substituted by Cl in BaCuTe to suppress the overhigh hole concentration.

HIV-1 Nef blocks the development of hematopoietic stem/progenitor cells into myeloid-erythroid lineage cells.

Background: A variety of hematopoietic abnormalities are commonly seen in human immunodeficiency virus-1 (HIV-1) infected individuals despite antiviral therapy, but the underlying mechanism remains elusive. Nef plays an important role in HIV-1 induced T cell loss and disease progression, but it is not known whether Nef participates in other hematopoietic abnormalities associated with infection.

Results: In the current study we investigated the influence of HIV-1 Nef (LAI Nef) on the development of hematopoietic stem/progenitor cells (HSPCs) into myeloid-erythroid lineage cells, and found that nef expression in HSPCs blocked their differentiation both in vitro and in humanized mice reconstituted with nef-expressing HSPCs.

HIV-1LAI Nef blocks the development of hematopoietic stem/progenitor cells into T lymphoid cells.

Objective: Despite successful antiviral therapy, the recovery of CD4+ T cells may not be complete in certain HIV-1-infected individuals. In our previous work with humanized mice infected with CXCR4-tropic HIV-1LAI (LAI), viral protein Nef was found the major factor determining rapid loss of both CD4+ T cells and CD4+CD8+ thymocytes but its effect on early T-cell development is unknown. The objective of this study is to investigate the influence of LAI Nef on the development of hematopoietic stem/progenitor cells (HSPCs) into T lymphoid cells.

Simultaneously Breaking the Double Schottky Barrier and Phonon Transport in SrTiO-Based Thermoelectric Ceramics via Two-Step Reduction.

The low powder factor (PF) of polycrystalline oxide perovskites induced by the resistive grain boundaries or known as double Schottky barrier (DSB) greatly restricts their thermoelectric performance in application. Here, a general protocol including (i) powder and (ii) bulk reduction in H/Ar forming gas is demonstrated to break the DSB in La and Nb codoped SrTiO. While the powder reduction guarantees a high carrier concentration by fully stimulating the donor doping effect, the bulk reduction effectively lowers the DSB by influencing the point defects at grain boundaries, which is proved by the combination of cathode luminescence spectra and energy-dispersive X-ray spectroscopy in transmission electron microscopy.

The protective efficacy of specific egg yolk immunoglobulin Y(IgY) against Riemerella Anatipestifer infections.

Riemerella anatipestifer (RA) is the significant pathogen of septicemia and duck infectious serositis, diseases which can result in high mortality for ducklings. However, these diseases are difficult to treat because of the bacteria's broad resistance to multiple drugs. The purpose of this study was to produce a specific egg yolk immunoglobulin Y (IgY) targeted to RA, and to evaluate the protective efficacy of this IgY against RA infection.

Dual layered wound dressing with simultaneous temperature & antibacterial regulation properties.

Scald first-aid needs to reduce the local temperature as well as the bacterial colonization. Bacteria resistant problem has become a major challenge that global public health workers face. Long-term and high dosage use of antibacterial agents is the main reason.

Small leucine rich proteoglycans in host immunity and renal diseases.

The small leucine rich proteoglycans (SLRPs), structurally consisting of protein cores and various glycosaminoglycan side chains, are grouped into five classes based on common structural and functional properties. Besides being an important structural component of extracellular matrix (ECM), SLRPs have been implicated in the complex network of signal transduction and host immune responses. The focus of this review is on SLRPs in host immunity.

Understanding and application of an electroplating sludge-derived catalyst with an active texture for improved NO reduction.

Industrial sludge has been shown to be a valuable source of transition metals and to be effective in NO reduction. This research has further revealed a characteristic texture (O-Me-C) that promotes effective NO reduction and supports its existence in a sludge-derived catalyst. HRTEM exhibited that the O-Me-C consisted of multi-metal-oxide core, carbon shell and their binding interfaces.

Lithium Expulsion from the Solid-State Electrolyte LiLaZrTaO by Controlled Electron Injection in a SEM.

The garnet ionic conductor is one of the promising candidate electrolytes for all-solid-state secondary lithium batteries, thanks to its high lithium ion conductivity and good thermal and chemical stability. However, its microstructure is difficult to approach because it is very sensitive to the inquisitive electron beam. In this study based on a scanning electron microscope (SEM), we found that the electron beam expulses the lithium out of LiLaZrTaO (LLZTO), and the expulsed zone expands to where a stationary beam could extend and penetrate.

Surface-tension-confined assembly of a metal-organic framework in femtoliter droplet arrays.

Metal-organic frameworks (MOFs), produced by metal ions coordinated to organic linkers, have attracted increasing attention in recent years. For the utilization in MOFs in numerous applications, achieving positioned MOF growth on surfaces is essential to fabricate multiple-functional devices. We develop a novel miniaturized method to realize surface-tension-confined assembly of HKUST-1 in femtoliter droplet arrays.

Lanthanum Chloride Inhibits LPS Mediated Expressions of Pro-Inflammatory Cytokines and Adhesion Molecules in HUVECs: Involvement of NF-κB-Jmjd3 Signaling.

Background/aims: To investigate the regulation of LaCl3 on lipopolysaccharides (LPS)-induced pro-inflammatory cytokines and adhesion molecules in human umbilical vein endothelial cells (HUVECs).

Methods: Primary cultured HUVECs were pretreated with 2.5 µM LaCl3 for 30 min followed by 1 µg/ml LPS for 2 h.

The regulation of Jmjd3 upon the expression of NF-κB downstream inflammatory genes in LPS activated vascular endothelial cells.

Inflammatory mediators and adhesion molecules have been implicated in a variety of diseases including atherosclerosis. As both the mediator-releasing and targeted cells, vascular endothelial cells play key role in pathological processes. NF-κB signaling regulates a cluster of inflammatory factors in LPS-activated vascular endothelial cells but the underlying mechanisms remain largely unknown.

Photoelectrochemical properties of nanomultiple CaFe2O4/ZnFe2O4 pn junction photoelectrodes.

Nanomultiple CaFe2O4/ZnFe2O4pn junctions are prepared by a pulsed laser deposition method to explore their photoelectrochemical properties as the photoelectrodes. It is demonstrated that the multiple-pn-junction structure is favorable to enhancing the photocurrent density and the onset potential of the photoelectrode. Furthermore, the 20-junction photoelectrode-based PEC cell yields a high open circuit photovoltage of up to 0.

[Observation on marrow-derived mesenchymal stem cells differentiating into functional cells in rabbit with smoke inhalation injury].

Objective: To observe the homing and differentiation of marrow-derived mesenchymal stem cells (MSC) transplanted intravenously in smoke inhalation injured rabbits.

Methods: Thirty-two New Zealand big ear rabbits were divided into normal control group (NC), inhalation injury group (II), normal control + MSC treatment group (NM), and MSC treatment group (MT) according to the random number table, with 8 rabbits in each group. Rabbits in NC group were injected with 10 mL phosphate buffered saline (PBS) via ear marginal vein.

[Effect of bone marrow-derived mesenchymal stem cells transplantation on the inflammatory response and lung injury in rabbit with inhalation injury].

Objective: To study the effect of bone marrow-derived mesenchymal stem cells (MSC) transplantation on the major inflammatory cytokines content in peripheral blood, lung water mass fraction, and lung tissue injury in rabbits with smoke inhalation injury.

Methods: Sixteen adult New Zealand big ear rabbits were subjected to smoke inhalation injury and then were divided into pure injury group (PI, n = 8) and MSC transplantation group (MT, n = 8) according to the random number table. Via ear marginal vein, rabbits in PI group were injected with 10 mL phosphate buffered saline (PBS); rabbits in MT group were injected with 10 mL PBS containing the third passage MSC (1 x 10⁷ cell) isolated from marrow of healthy young New Zealand big ear rabbit.

[Effects of glutamine enriched enteral feeding on immunoregulation in burn patients].

Objective: To investigate the effects of glutamine enriched enteral feeding on immunoregulation in burn patients.

Methods: Twenty burn patients were randomly divided into enteral nutrition (EN) group and enteral immune nutrition (EIN) group, with 12 patients in each group. Patients in EN group received a standard enteral formula, while those in EIN group received an enteral formula enriched with glutamine after hospital admission.