Publications by authors named "Juanhui Lin"
Article Synopsis
- - Severe acute pancreatitis (SAP) is a serious inflammatory condition of the pancreas with limited treatment options, prompting the development of a new nanotherapeutic called pHA@IBNCs to alleviate inflammation and restore intestinal health.
- - The pHA@IBNCs are formed by combining an antioxidant (EGCG), an anti-inflammatory cytokine (IL-22), and a framework protein (bovine serum albumin), then coated with a modified hyaluronic acid to target damaged cells in the pancreas and intestines.
- - When administered, the pHA@IBNCs effectively accumulate at inflammation sites, releasing their therapeutic agents in response to the high levels of reactive oxygen species (ROS) present, which helps reduce inflammation and
Oral delivery of small interfering RNA (siRNA) provides a promising paradigm for treating diseases that require regular injections. However, the multiple gastrointestinal (GI) and systemic barriers often lead to inefficient oral absorption and low bioavailability of siRNA. Technologies that can overcome these barriers are still lacking, which hinders the clinical potential of orally delivered siRNA.
View Article and Find Full Text PDFProtein therapy targeting the intracellular machinery holds great potentials for disease treatment, and therefore, effective cytosolic protein delivery technologies are highly demanded. Herein, we developed reactive oxygen species (ROS)-degradable, branched poly(β-amino ester) (PBAE) with built-in phenylboronic acid (PBA) in the backbone and terminal-pendent arginine for the efficient cytosolic protein delivery. The PBAE could form stable and cell-ingestible nanocomplexes (NCs) with proteins via electrostatic interaction, nitrogen-boronate (N-B) coordination, and hydrogen bonding, while it can be degraded into small segments by the over-produced HO in tumor cells to enable cytoplasmic protein release.
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