The Effect of Polymorphisms on Type 2 Diabetes Mellitus Susceptibility and Diabetic Complications in the Chinese Han Population.

Background: is downregulated in diabetes, which might be related to diabetes. We explored the effect of polymorphisms on the development of type 2 diabetes mellitus (T2DM) and diabetic complications.

Methods: The subjects consisted of 500 patients with T2DM and 501 healthy controls.

PDX1 and MC4R genetic polymorphisms are associated with type 2 diabetes mellitus risk in the Chinese Han population.

Background: Diabetes mellitus (DM) is a complex metabolic disease that is caused by a complex interplay between genetic and environmental factors. This research aimed to investigate the association of genetic polymorphisms in PDX1 and MC4R with T2DM risk.

Methods: The genotypes of 10 selected SNPs in PDX1 and MC4R were identified using the Agena MassARRAY platform.

Association between STAT4 gene polymorphism and type 2 diabetes risk in Chinese Han population.

Background: Evidence from genetic epidemiology indicates that type 2 diabetes (T2D) has a strong genetic basis. Activated STAT4 has an inflammatory effect, and STAT4 is an important mediator of inflammation in diabetes. Our study aimed to study the association between STAT4 single nucleotide polymorphisms (SNPs) and T2D susceptibility in Chinese Han population.