Publications by authors named "Juana Thomas"
Article Synopsis
- The study aimed to assess the effectiveness of adding bezlotoxumab to repeat fecal microbiota transplantation (FMT) for patients with recurrent Clostridioides difficile infections after a previous unsuccessful FMT.
- It was found that combining bezlotoxumab with a second FMT significantly increased the cure rate from 48% to 89%.
- The research highlights the importance of understanding how bezlotoxumab and FMT work together and suggests that similar strategies could apply to other treatments for preventing C. difficile infection recurrence.
Background & Aims: Fecal microbiota transplantation (FMT) emerged as rescue treatment for multiply recurrent Clostridioides difficile infections (rCDIs) nonresponsive to standard therapy. However, estimation of FMT efficacy varies among different protocols and formulations, while placebo-controlled clinical trials have excluded most rCDI patients because of medical comorbidities. This study aimed to determine the safety and effectiveness of capsule FMT (cap-FMT) and colonoscopy FMT (colo-FMT) for rCDI using standardized products in a large, multicenter, prospective, real-world cohort.
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