Publications by authors named "Juana Pereira-Bueno"

Article Synopsis
  • The study investigates how gestational age affects the risk of fetal death in sheep infected with Toxoplasma gondii, focusing on the mechanisms behind this relationship.
  • Pregnant sheep were infected at three different gestation stages (40, 90, and 120 days) to observe the impact on parasite load, lesions, and abortion rates over time.
  • Results indicated that gestational age significantly influences parasite development and the resulting lesions, with variations in abortion timing and parasite burden observed across the different gestation groups.
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Toxoplasma gondii and Neospora caninum are two major abortifacient protozoans in domestic small ruminants and cattle, respectively, and they also parasitize a wide range of wildlife. Numerous serosurveys have been conducted in wild ruminants worldwide. However, the potential effect of different ecosystems and management practices on these infections has not been investigated.

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Here, we analyzed histological findings and parasite burden in chronic Neospora caninum infection in BALB/c and ICR mice and studied the correlation between lesion severity and parasite load in brain. To obtain a better understanding of the infection, we examined the influence of various host pathogen factors. Groups of outbred (ICR) and inbred (BALB/c) mice were inoculated using several NC-1 parasite doses (4 x 10(5), 10(6), and 5 x 10(6) tachyzoites), inoculation routes (intraperitoneal and subcutaneous), and 3 immunosuppressive treatments (methylprednisolone, cyclophosphamide, and vinblastine).

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