Exploring the link between serum uric acid and colorectal cancer: Insights from genetic evidence and observational data.

Colorectal cancer (CRC) is a major cause of cancer-related mortality worldwide. Urate, known for its antioxidant properties, may influence CRC risk and prognosis, but research on this is limited. We used Mendelian randomization (MR) analysis to explore the causal relationship between serum urate levels and CRC risk.

Interannual temperature rise leads to more uniform phenological matching between invasive and pollinators across elevations.

Exploring how environmental changes induce alterations in the phenology matching between plants and pollinators is significant for predicting species' reproductive output and population dynamics. Our study focused on the invasive poisonous weed , widely distributed in the Qilian Mountains, China. By continuously monitoring its flowering phenology and flower visitors' activities across different elevational ranges, we compared phenological matching patterns between and its potential pollinators across years with varying environmental temperatures.

A case report of empyema caused by Enterococcus gallinarum.

Background: Enterococcus gallinarum is an infrequently intestinal symbiotic pathogen associated with nosocomial infection in immunocompromised individuals. To date, rare cases of pulmonary infection attributable to Enterococcus gallinarum were reported. Herein, we presented the first case of empyema resulting from Enterococcus gallinarum infection.

Time-Dependent Sequential Changes of IL-10 and TGF-β1 in Mice with Deep Vein Thrombosis.

Objectives: To detect the expression changes of interleukin-10 (IL-10) and transforming growth factor-β1 (TGF-β1) during the development of deep vein thrombosis in mice, and to explore the application value of them in thrombus age estimation.

Methods: The mice in the experimental group were subjected to ligation of inferior vena cava. The mice were sacrificed by excessive anesthesia at 1 d, 3 d, 5 d, 7 d, 10 d, 14 d and 21 d after ligation, respectively.

Clinical characteristics of cerebral amyloid angiopathy and risk factors of cerebral amyloid angiopathy related intracerebral hemorrhage.

Objectives: There is limited understanding of the differences between cerebral amyloid angiopathy (CAA) with and without intracerebral hemorrhage (ICH). This article aimed to describe the characteristics of CAA and identify the risk factors of CAA-ICH in a multicenter cohort.

Methods: Patients consecutively enrolled in the national multicenter prospective Cerebral Small Vessel Disease Cohort Study who met the Boston diagnostic criteria for CAA or CAA-related inflammation were included in this study.

Characterization and Discrimination of Marigold Oleoresin from Different Origins Based on UPLC-QTOF-MS Combined Molecular Networking and Multivariate Statistical Analysis.

Marigold oleoresin is an oil-soluble natural colorant mainly extracted from marigold flowers. Xinjiang of China, India, and Zambia of Africa are the three main production areas of marigold flowers. Therefore, this study utilized ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS/MS) technology, combined with Global Natural Products Social Molecular Networking (GNPS) and multivariate statistical analysis, for the qualitative and discriminant analysis of marigold oleoresin obtained from three different regions.

The time-dependent expression of FPR2 and ANXA1 in murine deep vein thrombosis model and its relation to thrombus age.

Thrombus age determination in fatal venous thromboembolism cases is an important task for forensic pathologists. In this study, we investigated the time-dependent expressions of formyl peptide receptor 2 (FPR2) and Annexin A1 (ANXA1) in a stasis-induced deep vein thrombosis (DVT) murine model, with the aim of obtaining useful information for thrombus age timing. A total of 75 ICR mice were randomly classified into thrombosis group and control group.

Pollinator peaking earlier than flowering is more detrimental to plant fecundity.

Climate change has caused asynchronous phenological shifts between most plants and their pollinators, resulting in an earlier or later appearance of peak flowering relative to peak pollinator abundance. The fitness impact of these two mismatch patterns may not be simply equivalent, but the information has so far been limited. To explore how differently plant fitness responds to the distinct mismatch patterns, we conducted a seed-setting comparative study at the individual level in an alpine grassland community in the Qilian Mountains of China.

Preliminary Study on Total Component Analysis and In Vitro Antitumor Activity of Leaf Residues.

is widely introduced and cultivated in Yunnan province. Its foliage is mainly used to extract eucalyptus oil, but the by-product eucalyptus residue has not been fully utilized. Based on the above reasons, in this study, we sought to explore the comprehensive utilization potential of eucalyptus resources.

Analysis of 5-Year-old children's oral health service utilization and influencing factors in Guizhou Province, China (2019-2020).

Background: This study aimed to investigate the utilization patterns and factors related to oral health care for 5-year-old preschoolers based on Andersen's Behavioural Model in Guizhou Province, Western China.

Method: A cross-sectional study of 4,862 5-year-old preschoolers in 66 kindergartens was conducted in 2019 and 2020. A basic oral examination and a survey of parents and grandparents were conducted to gather data on oral health services.

Mitochondria-targeting two-photon fluorescent probe for sequential recognition of Cu and ATP in neurons and zebrafish.

Highly active mitochondria play a significant role in neuron function. Cu and ATP levels in mitochondria regulate neuronal mitochondrial activity. However, mitochondrial activity was often evaluated by mitochondrial membrane potential.

Study on the Key Genes and Molecular Mechanisms of IL-27 Promoting Keratinocytes Proliferation Based on Transcriptome Sequencing.

Background: IL-27 involves psoriasis pathogenesis potentially by promoting excessive keratinocyte proliferation. However, the underlying mechanisms remain unclear. This study aims to explore the key genes and molecular mechanisms of IL-27-induced keratinocyte proliferation.

Acute cold stress induces intestinal injury via CIRP-TLR4-IRE1 signaling pathway in pre-starter broilers.

Background: Cold stress is a common environmental stress in broiler chicks. Cold-inducible RNA-binding protein (CIRP) is a conserved cold shock protein that can regulate inflammatory response through Toll-like receptor 4 (TLR4). The mechanism that how CIRP involves in the regulation of cold stress in broilers remains unclear.

Recent Advancement of PD-L1 Detection Technologies and Clinical Applications in the Era of Precision Cancer Therapy.

Programmed death-1 is a protein found on the surface of immune cells that can interact with its ligand, programmed death-ligand 1 (PD-L1), which is expressed on the plasma membrane, the surface of secreted cellular exosomes, in cell nuclei, or as a circulating soluble protein. This interaction can lead to immune escape in cancer patients. In clinical settings, PD-L1 plays an important role in tumor disease diagnosis, determining therapeutic effectiveness, and predicting patient prognosis.

Mechanisms of in-hospital acute ischemic stroke and their relevance to prognosis: A retrospective analysis.

Objectives: In-hospital stroke (IHS) is common and has a poor prognosis. Limited data were about the mechanisms of IHS, posing a challenge in taking measures to prevent stroke during hospitalization. This study aims to investigate the mechanisms of IHS and their relevance to prognosis.

Copper and Palladium Cocatalyzed Defluorinative Coupling of -Difluoroalkenes and Acyl Chloride.

A novel copper and palladium cocatalyzed defluorinative coupling of -difluoroalkenes and acyl chlorides has been developed. It is a practical method to prepare -fluorochalcones, which are a kind of important unit in a variety of bioactive compounds. Under mild reaction conditions, a series of substrates with various functional groups could afford desired products smoothly.

Distinct lesion features and underlying mechanisms in patients with acute multiple infarcts in multiple cerebral territories.

Objective: To determine the etiology spectrum and lesion distribution patterns of patients with acute multiple infarcts in multiple cerebral territories (AMIMCT) and provide guidance for treatment and prevention strategies in these patients.

Methods: Patients with acute ischemic stroke diagnosed using diffusion-weighted imaging (DWI) were consecutively included in this study between June 2012 and Apr 2022. AMIMCT was defined as non-contiguous focal lesions located in more than one cerebral territory with acute neurological deficits.

Effect of silver-containing hydrofiber dressing on burn wound healing: A meta-analysis and systematic review.

Background: Silver sulfadiazine is commonly used to treat local burn wounds. Aquacel-Ag is a hydrogen fiber dressing containing ionic silver that reduces burn wound infection and promotes antimicrobial activity. It is necessary to compare the efficacy of the two in the healing of burns.

Comparative assessment on ammonia nitrogen adsorption onto a saline soil-groundwater environment: distribution, multi-factor interaction, and optimization using response surface methodology and artificial neural network.

The adsorption of soil can reduce the leaching of NH-N from the external environment into groundwater. The adsorption of NH-N is affected by many factors. It is critical to use statistical model to quantitatively describe the effects of interaction between two or more factors on the system response.

Efficient removal of microplastics from aqueous solution by a novel magnetic biochar: performance, mechanism, and reusability.

Microplastics' (MPs) pollution removal from water bodies has become an urgent task to ensure water quality safety and water ecological security on a global scale. In this work, coprecipitation was employed to investigate the adsorption of MPs by magnetic biochar (MRB) prepared from agricultural waste rice husks in an aquatic system. The results showed that MRB can adsorb up to 99.

Inhibition of ANGPT2 activates autophagy during hypertrophic scar formation via PI3K/AKT/mTOR pathway.

Background: Hypertrophic scar (HS), a fibroproliferative disorder caused by aberrant wound healing following skin injuries such as burns, lacerations and surgery, is characterized by invasive proliferation of fibroblasts and excessive extracellular matrix (ECM) accumulation. The dysregulation of autophagy is the pathological basis of HS formation. Previously, angiopoietin-2 (ANGPT2) was found to be overexpressed in HS fibroblasts (HSFs) compared with normal skin fibroblasts.

Sanzi Yangqin Decoction Alleviates Allergic Asthma by Modulating Th1/Th2 Balance: Coupling Network Pharmacology with Biochemical Pharmacology.

This study aimed to verify that Sanzi Yangqin Decoction (SYD) can relieve asthma in mice and explore the effect on TH1/Th2 balance. The targets of SYD and asthma were explored from the public database using various methods. The potential targets and signaling pathways were identified by KEGG enrichment analysis from DAVID database.

Characteristics of fluoride migration and enrichment in groundwater under the influence of natural background and anthropogenic activities.

Excessive enrichment of fluoride threatens ecological stability and human health. The high-fluoride groundwater in the Chagan Lake area has existed for a long time. With the land consolidation and irrigation area construction, the distribution and migration process of fluoride have changed.

The Mechanisms of the Potential Probiotic against Cardiovascular Disease and the Recent Developments in its Fermented Foods.

Cardiovascular disease (CVD) has become the leading cause of death worldwide. Many recent studies have pointed out that ( has great potential in reducing the risk of CVD. is a kind of lactic acid bacteria (LAB) widely distributed in fermented food and the human intestinal tract, some strains of which have important effects on human health and the potential to be developed into probiotics.