Publications by authors named "Juan-Ying Wu"
[Expression of HIF-1α in primary acute myeloid leukemia cells and its relationship with prognosis].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
February 2015
Article Synopsis
- - This study investigated the role of HIF-1α expression in acute myeloid leukemia (AML) and its correlation with clinical outcomes, examining samples from 53 newly diagnosed patients.
- - Results showed that HIF-1α levels did not significantly relate to age, sex, or other standard clinical factors, but higher expression was noted in patients who did not achieve complete remission and had a higher relapse rate.
- - The findings suggest that elevated HIF-1α is associated with extramedullary infiltration in AML and could serve as an early indicator of poor prognosis in these patients.
All-trans retinoic acid (ATRA) and arsenic trioxide (As2O3) are the classic drugs used for induction therapy of acute promyelocytic leukemia (APL). IL-3Ralpha (CD123) is a specific marker of acute myeloid leukemia stem cells (AML-LSCs). The over-expression of IL-3Ralpha in patients with AML is related to high white blood cells counts, high percentages of blast cells, and poor prognosis.
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