Publications by authors named "Juan-Li Yan"
[Low-frequency pulsed electromagnetic fields promotes rat osteoblast differentiation in vitro through cAMP/PKA signal pathway].
Nan Fang Yi Ke Da Xue Xue Bao
November 2016
Article Synopsis
- The study aims to determine if low-frequency pulsed electromagnetic fields (PEMF) can enhance the differentiation of rat osteoblasts through the cAMP/PKA signaling pathway.
- Rat osteoblasts were subjected to a specific PEMF and analyzed for changes in cAMP levels and PKA phosphorylation at different time intervals, alongside testing with inhibitors to assess their impact on osteogenic activity.
- Results indicate that PEMF exposure boosts cAMP concentration and PKA levels initially, with significant increases in alkaline phosphatase activity and osteogenic gene transcription, suggesting that PEMF enhances osteoblast differentiation via the cAMP/PKA pathway.
Although pulsed electromagnetic fields (PEMFs) have been approved as a therapy for osteoporosis, action mechanisms and optimal parameters are elusive. To determine the optimal intensity, exposure effects of 50 Hz PEMFs of 0.6-3.
View Article and Find Full Text PDFEffect of sinusoidal electromagnetic field on bone mineral density and histomorphometry of rats at different time points.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
December 2014
Objective: To investigate the effect of 50 Hz 0.1 mT sinusoidal electromagnetic field at different time points on bone mineral density(BMD)and histomorphometry in rats.
Methods: Totally 50 6-week-old female SD rats were equally randomized into 5 groups: control group,45-minute group,90-minute group,180-minute group,and 270-minute group.
Effects of sinusoidal electromagnetic fields (SEMFs) on bone metabolism have not yet been well defined. The present study investigated SEMF effects on bone formation and resorption in rat femur bone tissues in vitro. Cultured femur diaphyseal (cortical bone) and metaphyseal (trabecular bone) tissues were treated with 50 Hz 1.
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