Publications by authors named "Juan-Hua Wang"
[Relationship between serum HBV DNA level and follicular helper T lymphocyte in patients with chronic hepatitis B and its significance].
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
October 2013
Objective: To explore relationship between HBV DNA level and peripheral blood follicular helper T lymphocyte (Tfh) in patients with chronic hepatitis B (CHB) and its significance.
Methods: HBV DNA levels of 179 cases of CHB patients with positive HBV DNA, positive HBeAg and positive human leukocyte antigen(HLA)-A2 were tested with real time fluorescent quantitative PCR. Tfh and HBV specific CTL were tested with flow cytometry.
[Difference of HBV DNA levels and HBV genotypes between the patients with primary hepatocellular carcinoma and liver cirrhosis with hepatitis B].
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
August 2011
Objective: To compare the difference of HBV DNA levels and HBV genotypes between the patients with primary hepatocellular carcinoma (HCC) and liver cirrhosis who infected with hepatitis B virus.
Methods: Total 430 patients with hepatitis B were enrolled and further divided into the HCC group (210 cases) and liver cirrhosis group (HBV LC, 220 cases). The levels of HBV DNA and HBV genotypes were detected in all of the serum samples from the two groups, and the differences in the genotypes and virological markers between HCC patients and HBV LC patients were further analyzed.
[Relationship between viral genotype and specific and nonspecific CTL of patients with cirrhotic hepatitis B and its significance].
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
June 2011
Article Synopsis
- The study investigates the relationship between HBV genotypes and the immune response of patients with cirrhotic hepatitis B, focusing on cytotoxic T lymphocytes (CTL).
- Among 91 patients, genotype C was more prevalent (60.44%) compared to genotype B (38.46%), with genotype C showing lower HBV-specific CTL levels.
- Findings indicate that patients with genotype C not only had lower HBV-specific CTL levels but also higher HBV DNA levels and liver damage markers, suggesting a more severe disease progression compared to genotype B.