Prognostic value of serum angiopoietin-like protein 2 in patients with acute coronary syndrome.

Background: Angiopoietin-like protein 2 (Angptl2) is a cytokine that is released to stimulate inflammation and accelerate atherogenesis. Our study sought to assess the predictive significance of serum Angptl2 in individuals diagnosed with acute coronary syndrome (ACS) and determine whether it can enhance prognostic performance beyond the GRACE risk score.

Methods: We recruited a total of 1060 patients with ACS in a consecutive manner.

Interaction between sex and one-hour post-load glucose on metabolic syndrome and its components among Chinese people at high risk of diabetes.

Background: Recently, International Diabetes Federation position statement has adopted one-hour post-load glucose (1hPG) ≥ 8.6 mmol/L for diagnosing intermediate hyperglycemia. We aimed to assess the association of 1hPG ≥ 8.

Identify unmet needs in diabetes care in Shandong, China: a secondary analysis of a cross-sectional study using cascade of care framework.

Background: The continuum management of diabetes remains under-evaluated in China. This study aimed to estimate the proportions of diabetes adults at each stage of the cascade of care framework in Shandong, China.

Methods: We conducted a secondary analysis using the 2018 China Adult Chronic Disease and Nutrition Surveillance (CACDNS) data in Shandong.

[IgA vasculitis with necrosis of the small intestine secondary to monoclonal gammopathy of renal significance: A case report].

Monoclonal gammopathy of undetermined significance combined with renal damage is named monoclonal gammopathy of renal significance. There are few reports about IgA vasculitis in patients with monoclonal gammopathy of undetermined significance. Here, we report a case of monoclonal gammopathy of renal significance, who had manifestations of IgA vasculitis, including purpura, gastrointestinal bleeding and joint pain.

The plant signal peptide CLE7 induces plant defense response against viral infection in Nicotiana benthamiana.

In plants, small peptides are important players in the plant stress response, yet their function in plant antiviral responses remains poorly understood. Here, we identify that the plant small peptide, CLAVATA3/ESR-RELATED 7 (CLE7), enhances plant resistance to Chinese wheat mosaic virus infection in Nicotiana (N.) benthamiana.

Therapeutic Targets and Natural Product Screening for Cognitive Impairments Associated with Ferroptosis in Wilson's Disease.

Wilson's disease (WD) is a hereditary condition marked by abnormalities in copper metabolism, which precipitate a spectrum of neurological symptoms and cognitive impairments. Emerging research has highlighted ferroptosis (FPT) as a distinct type of programmed cell death, potentially linked to various cognitive dysfunctions. Nevertheless, the connection between FPT and cognitive impairment in Wilson's disease (WDCI) remains largely enigmatic.

Pathogenesis of acephalic spermatozoa syndrome caused by PMFBP1 mutation.

Background: Acephalic spermatozoa syndrome is a rare but severe type of teratozoospermia. The familial trait of acephalic spermatozoa syndrome suggests that genetic factors play an important role. However, known mutations account for only some acephalic spermatozoa syndrome patients, and more studies are needed to elucidate its pathogenesis.

Predicting the likelihood of germline pathogenic variants in unselected patients with breast cancer: analysis of more than 10,000 individuals.

Background: Models for accurately predicting the likelihood of germline pathogenic variants (PVs) based on a large cohort of unselected patients with breast cancer are limited.

Methods: A logistic regression model to predict the carrier probability, named PKCBRCA, was established and validated based on 10 167 unselected Chinese patients with breast cancer treated in Peking University Cancer Hospital between October 2003 and August 2020. All patients were tested for germline variants.

Design and synthesis of N-(3-cyanothiophen-2-yl)-2-phenoxyacetamide-based α-glucosidase inhibitors.

This study investigates the design and synthesis of a series of novel selective α-glucosidase inhibitors based on N-(3-cyanothiophen-2-yl)-2-phenoxyacetamide framework, employing a bioisosterism strategy. Among the nineteen newly synthesized analogs, compound 4d9 demonstrated the highest α-glucosidase inhibitory potency (IC = 2.11 μM) when compared to the established inhibitors Acarbose (IC = 327.

A multimodal travel route recommendation system leveraging visual Transformers and self-attention mechanisms.

Introduction: With the rapid development of the tourism industry, the demand for accurate and personalized travel route recommendations has significantly increased. However, traditional methods often fail to effectively integrate visual and sequential information, leading to recommendations that are both less accurate and less personalized.

Methods: This paper introduces SelfAM-Vtrans, a novel algorithm that leverages multimodal data-combining visual Transformers, LSTMs, and self-attention mechanisms-to enhance the accuracy and personalization of travel route recommendations.

Interactions between ferroptosis and tumour development mechanisms: Implications for gynaecological cancer therapy (Review).

Ferroptosis is a form of programmed cell death that is distinct from apoptosis. The mechanism involves redox‑active metallic iron and is characterized by an abnormal increase in iron‑dependent lipid reactive oxygen species, which results in high levels of membrane lipid peroxides. The relationship between ferroptosis and gynaecological tumours is complex.

Extraction, purification, structural characterization, bioactivities, modifications and structure-activity relationship of polysaccharides from : a review.

(Thunb.) Ker Gawl., is a traditional Chinese medicine (TCM) with a history of thousands of years.

Leveraging multi-level correlations for imputing monitoring data in water supply systems using graph signal sampling theory.

Data missing and anomalies in monitoring equipment have become critical barriers to developing intelligent Water Supply Systems (WSS). The valid data preceding and after the missing segments can be utilized to impute missing values. However, traditional imputation methods, such as linear interpolation and prediction-based methods, have limited capacity to use data relationships or can only utilize information before the missing values.

Corrigendum: Integrated metagenomics and metabolomics analyses revealed biomarkers in β-casein A2A2-type cows.

[This corrects the article DOI: 10.3389/fvets.2024.

Differential Expressions of circRNAs and Regulatory Mechanisms of ceRNA Network in Liver of Wilson's Disease TX Mice.

Background: Wilson's disease (WD) is a hereditary disorder characterized by an abnormality in copper metabolism. Liver fibrosis, and potentially cirrhosis, induced by copper accumulation are critical factors in the pathogenesis of WD. CircRNAs exhibit high stability and play crucial roles in numerous biological processes.

Comparison of Effects between Nasal Bi-Level Positive Airway Pressure and Nasal Synchronized Intermittent Mandatory Ventilation in Neonatal Respiratory Distress Syndrome.

Neonatal respiratory distress syndrome (NRDS) is characterized by progressive aggravation and rapid progression of respiratory distress, with a high incidence rate among premature infants. If left untreated, NRDS results in a poor prognosis. In recent years, various respiratory support modalities have received extensive attention in clinical practice.

Machine learning-based ultrasomics for predicting response to tyrosine kinase inhibitor in combination with anti-PD-1 antibody immunotherapy in hepatocellular carcinoma: a two-center study.

Objective: The objective of this study is to build and verify the performance of machine learning-based ultrasomics in predicting the objective response to combination therapy involving a tyrosine kinase inhibitor (TKI) and anti-PD-1 antibody for individuals with unresectable hepatocellular carcinoma (HCC). Radiomic features can reflect the internal heterogeneity of the tumor and changes in its microenvironment. These features are closely related to pathological changes observed in histology, such as cellular necrosis and fibrosis, providing crucial non-invasive biomarkers to predict patient treatment response and prognosis.