Root-associated bacterial microbiome shaped by root selective effects benefits phytostabilization by Athyrium wardii (Hook.).

The root-associated microbiome assembly substantially promotes (hyper)accumulator plant growth and metal accumulation and is influenced by multiple factors, especially host species and environmental stress. Athyrium wardii (Hook.) is a phytostabilizer that grows in lead (Pb)-zinc (Zn) mine tailings and shows high root Pb accumulation.

New insights into the key role of node I in thallium accumulation in seed of coix (Coix lacryma-jobi L.).

The mechanisms underlying the distribution of many toxic metal(loid)s in shoots and metal(loid) transport to grains have been well documented in the quest for food safety but there remains a lack of knowledge on thallium (Tl) accumulation in food crops. Here, field investigations combined with a glasshouse pot experiment were conducted to investigate the characteristics of Tl distribution and accumulation in coix, a major food crop in south Guizhou province, China, and the role of node I in restricting Tl transport to the seed. Fourteen percent of coix seed samples collected from the Lanmuchang Tl-As-Hg mine contained higher Tl concentrations than the recommended limit for foods and feedstuffs in Germany (0.

Clinical characteristics of bloodstream infections in adult patients with solid tumours and a nomogram for mortality prediction: a 5-year case-controlled retrospective study in a tertiary-level hospital.

Background: Bloodstream infections (BSIs) are one of the leading causes of death in cancer patients. Nevertheless, the risk factors of BSIs in solid tumors have rarely been ascertained adequately.

Methods: We conducted a single-center case-controlled retrospective study from 2017 to 2021 among adults with solid tumors in a tertiary-level hospital.

Role of Root Exudates in Cadmium Accumulation of a Low-Cadmium-Accumulating Tobacco Line ( L.).

Root exudates are tightly linked with cadmium (Cd) uptake by the root and thus affect plant Cd accumulation. A hydroponic experiment was carried out to explore the role of root exudates in Cd accumulation of a low-Cd-accumulating tobacco line (RG11) compared with a high-Cd- accumulating tobacco line (Yuyan5). Greater secretion of organic acids and amino acids by the roots was induced by an exogenous Cd addition in the two tobacco lines.

Depletion of macrophages with clodronate liposomes partially attenuates renal fibrosis on AKI-CKD transition.

Clodronate liposomes are bisphosphonates encapsulated by liposomes that are known to induce macrophage depletion . In a previous study, clodronate liposomes improved renal ischemia/reperfusion (I/R) injury in mice, which may be due to effects on macrophage phenotypes. However, how inflammatory cytokines secretion participates is unknown.

The investigation of construction and clinical application of image recognition technology assisted bronchoscopy diagnostic model of lung cancer.

Background: The incidence and mortality of lung cancer ranks first in China. Bronchoscopy is one of the most common diagnostic methods for lung cancer. In recent years, image recognition technology(IRT) has been more and more widely studied and applied in the medical field.

Indigenous rhizosphere microbial community characteristics of the phytostabilizer Athyrium wardii (Hook.) grown in a Pb/Zn mine tailing.

Plant rhizosphere microbiome usually changes dramatically in adaptation to the mine environment to endure high heavy metal concentration, which in turn improves the process of revegetation and phytostabilization of mine tailing and deserves deep investigation. A field study was conducted to investigate the indigenous microbial community of a mining ecotype (ME) of the phytostabilizer Athyrium wardii (Hook.) grown in a Pb/Zn mine tailing and a corresponding non-mining ecotype (NME) grown in an uncontaminated adjacent site.

The Global, Regional, and National Burden and Trends of Infective Endocarditis From 1990 to 2019: Results From the Global Burden of Disease Study 2019.

Introduction: Infective endocarditis (IE) presents with increasing incidence and mortality in some regions and countries, as well as serious socioeconomic burden. The current study aims to compare and interpret the IE burden and temporal trends globally and in different regions from 1990 to 2019.

Methods: Data on the incidence, deaths and disability-adjusted life years (DALYs) caused by IE were extracted and analyzed from the Global Burden of Disease Study 2019.

Global, regional, and national burden of urinary tract infections from 1990 to 2019: an analysis of the global burden of disease study 2019.

Purpose: We aimed to estimate the burden of UTIs by age, sex, and socioeconomic status in 204 countries and territories from 1990 to 2019.

Methods: We used data from Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to analyse the incidence, mortality, and disability-adjusted life-years (DALYs) due to UTIs at the global, regional, and national levels. Estimates are presented as numbers and age-standardised or age-specific rates per 100,000 population, with 95% uncertainty intervals (UIs).

A composite amendment benefits rice (Oryza sativa L.) safety and production in cadmium-contaminated soils by unique characteristics after oxidation modification.

In-situ immobilization is an effective strategy for Cd remediation and food safety, while some modifications are necessary to improve immobilization efficiency. In this study, a composite amendment (RFW) derived from rice straw biochar (RSB), fly ash (FA), and white marble (WM) was modified by oxidization (RFW-O) and pyrolysis (RFW-P). The RFW-O showed stronger Cd sorption ability than RFW and RFW-P due to larger BET surface area and more oxygen containing-functional groups.

The changes of rhizosphere characteristics contributed to enhanced Pb accumulation in Athyrium wardii (Hook.) Makino after nitrilotriacetic acid application.

Chelant-assisted phytoremediation may modify plant rhizosphere, which is closely related to heavy metal (HM) accumulation in plants. This work focused on the effects of nitrilotriacetic acid (NTA) on rhizosphere characteristics to investigate the mechanisms of lead (Pb) accumulation in Athyrium wardii (Hook.) Makino with exposure to 800 mg kg Pb.

MiR-3130-5p is an intermediate modulator of 2q33 and influences the invasiveness of lung adenocarcinoma by targeting NDUFS1.

Genome-wide association studies (GWAS) have reported a handful of loci associated with lung cancer risk, of which the pathogenic pathways are largely unknown. We performed cis-expression quantitative trait loci (eQTL) mapping for 376 lung cancer related GWAS loci in 227 TCGA lung adenocarcinoma (LUAD) and reported two risk loci as eQTL of miRNA. Among the miRNAs in association with lung cancer risk, we further predicted and validated miR-3130-5p as an intermediate modulator of risk loci 2q33 and the tumor suppressor NDUFS1.

Global, regional, and national dengue burden from 1990 to 2017: A systematic analysis based on the global burden of disease study 2017.

Background: Dengue is one of the most common vector-borne diseases globally, however, its burden is poorly quantified. Hence, we aimed to report the dengue burden in 195 countries and territories between 1990 and 2017, using data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017.

Methods: Following the methodology framework and analytical strategies used in the Global Burden of Disease Study 2017, we analysed the incidence, mortality, and disability-adjusted life years (DALYs) of dengue in geographically defined populations worldwide between 1990 and 2017.

Early fibroproliferative signs on high-resolution CT are associated with mortality in COVID-19 pneumonia patients with ARDS: a retrospective study.

Objectives: To investigate the chest high-resolution computed tomography (HRCT) findings in coronavirus disease 2019 (COVID-19) pneumonia patients with acute respiratory distress syndrome (ARDS) and to evaluate its relationship with clinical outcome.

Materials And Methods: In this retrospective study, 79 COVID-19 patients with ARDS were recruited. Clinical data were extracted from electronic medical records and analyzed.

The predominant role of pectin in binding Cd in the root cell wall of a high Cd accumulating rice line (Oryza sativa L.).

Cell wall (CW) plays an important role in Cd accumulation in roots of metal-tolerant plants, including rice. The role of CW polysaccharides, especially pectin, in binding Cd in roots of a high Cd accumulating (HA) rice line of Lu527-8 and a non-high Cd accumulating (NHA) rice line of Lu527-4 was investigated in this study. About 59%-63% of Cd in roots of the two rice lines was bound to CWs, indicating that CW was the main site for Cd accumulation in roots of the two rice lines.

Medical students mental health, professional pride, and intention to work in the frontline during coronavirus disease 2019 pandemic.

Objectives: To understand medical students' mental health, professional pride, and intention to work in the front-line during coronavirus disease 2019 (COVID-19) pandemic, and provide a reference for psychological intervention.

Methods: We used the depression-anxiety-stress scale and self-designed questionnaire on professional pride, intention to work in the front-line and the extent of family support. Medical students from 4 medical schools in Fujian and Hunan were investigated.

Characterization of dissolved organic matter in the rhizosphere of phytostabilizer Athyrium wardii (Hook.) involved in enhanced metal accumulation when exposed to Cd and Pb co-contamination.

The characterization of DOM and its effect on heavy metal solubility in soils have been widely concerned, while few concerns on the phytostabilization of multi-metal contaminated soils. A pot experiment was performed to characterize dissolved organic matter (DOM) in the rhizosphere of the mining ecotype (ME) and non-mining ecotype (NME) of Athyrium wardii (Hook.) when exposed to Cd and Pb simultaneously, and investigate its effect on Cd and Pb solubility in soils.

NTA-enhanced Pb remediation efficiency by the phytostabilizer Athyrium wardii (Hook.) and associated Pb leaching risk.

Nitrilotriacetic acid (NTA), a biodegradable chelant, has been promoted to effectively assist Pb phytoextraction, while a few researches available on the phytostabilizer of Athyrium wardii (Hook.). In this study, two incubation experiments and a subsequent column experiment were conducted to investigate the effects of application of NTA on Pb availability in soils and Pb accumulation in A.

GSPE alleviates renal fibrosis by inhibiting the activation of C3/ HMGB1/ TGF-β1 pathway.

Grape seed proanthocyanidin extract (GSPE) has been reported to exhibit a variety of protective effects, such as antioxidant, anti-atherosclerosis and other pharmacological effects. As a member of the complement system, complement component 3 (C3) deposition in the glomerulus is recognized as an important causative mediator of various kidney diseases. In this study, we aimed to identify the effect of GSPE on C3 in the chronic kidney fibrosis and evaluate the possible mechanism.

The combined effects of Cd and Pb enhanced metal binding by root cell walls of the phytostabilizer Athyrium wardii (Hook.).

Cell wall acts as a major metal sink in plant roots, while a few studies focused on root cell wall binding in plants for the phytostabilization of multi-metal contaminated soils. A pot experiment was performed to characterize root cell wall properties of the mining ecotype (ME) and non-mining ecotype (NME) of Athyrium wardii (Hook.) in response to Cd and Pb.

Lead accumulation and soil microbial activity in the rhizosphere of the mining and non-mining ecotypes of Athyrium wardii (Hook.) Makino in adaptation to lead-contaminated soils.

Better understanding of microbial activity in the rhizosphere soils associated with lead (Pb) uptake by plants may help with the phytoremediation of Pb-contaminated soils. In this work, the effects of Pb exposure (0, 200, 400, 600, 800 mg kg) on Pb accumulation and soil microbial activity in the rhizosphere of the mining ecotype (ME) and corresponding non-mining ecotype (NME) of Athyrium wardii (Hook.) Makino were investigated through a pot experiment.

Cd and Pb accumulation characteristics of phytostabilizer Athyrium wardii (Hook.) grown in soils contaminated with Cd and Pb.

Interactions between heavy metals in soil could affect soil heavy metal availability and plant uptake. Thus, in this study, Cd and Pb accumulation as well as plant growth of the mining ecotype (ME) and non-mining ecotype (NME) of Athyrium wardii (Hook.) in response to the exposure of Cd and Pb was investigated by a pot experiment.

GSPE Inhibits HMGB1 Release, Attenuating Renal IR-Induced Acute Renal Injury and Chronic Renal Fibrosis.

Grape seed proanthocyanindin extract (GSPE) is a polyphenolic bioflavonoid derived from grape seeds and has been widely studied for its potent antioxidant, anti-inflammatory and antitumor activities. HMGB1 is a newly discovered danger-associated molecular pattern (DAMP) that has potent proinflammatory effects once released by necrotic cells. However, the effect of GSPE on the HMGB1, and the relationship of those two with acute kidney injury and chronic kidney fibrosis are unknown.

The influence of humic substance on Cd accumulation of phytostabilizer Athyrium wardii (Hook.) grown in Cd-contaminated soils.

The application of organic amendments into heavy metal contaminated soil is considered as an environmentally friendly technique to promote the potential of phytoremediation. A pot experiment was carried out to evaluate the effect of humic substances on growth, cadmium (Cd) accumulation and phytostabilization potential of the mining ecotype (ME) and the corresponding non-mining ecotype (NME) of Athyrium wardii (Hook.) grown in Cd-contaminated soils.