Associations between blood ethylene oxide levels and serum neurofilament light chain concentrations in adults: evidence from the NHANES.

Background: Ethylene oxide (EO) is a widely used industrial chemical recognized for its health risks, potentially posing threats to human health, including neurotoxicity, cardiovascular damage, and carcinogenic effects. Neurofilament light chain (NfL) is a protein released into the blood following axonal damage. To date, no studies have investigated the relationship between EO exposure and NfL levels.

Diagnostic significance of combined two-dimensional ultrasound and three-dimensional tomographic ultrasound imaging for cleft palate in fetus of 11-13 + 6 weeks: a prospective study.

Purpose: Clinical screening for cleft palate in fetus currently focuses on weeks 20-24. It has been shown that cleft palate can be detected by ultrasound in first-trimester anatomy scan, but there are no large-scale samples to validate. This study was to confirm the ability of combined two-dimensional(2D)-ultrasound and three-dimensional(3D)-tomographic ultrasound imaging (TUI) to safely detect an fetal cleft palate at 11-13 + 6 weeks large-scale samples.

Research progress in the regulation of endothelial cells and smooth muscle cells using a micro-nanostructure.

Recently, the incidence rate and mortality of various acute or chronic vascular occlusive diseases have increased yearly. As one of the most effective measures to treat them, vascular stents have been widely studied by researchers, and presently, the most commonly used is a drug-eluting stent, which reduces the process of rapid endothelialization because the drug is not selective. Fortunately, with the discovery and exploration of micro-nanostructures that can regulate cells selectively, reducing the incidence of "intravascular restenosis" and achieving rapid endothelialization simultaneously are possible through a special structure that cannot only improve endothelial cells (ECs), but also inhibit smooth muscle cells (SMCs).

Development and prospect of near-infrared spectroscopy-assisted schizophrenia diagnosis based on bibliometrics.

In this editorial, we comment on the recent article by Fei exploring the field of near-infrared spectroscopy (NIRS) research in schizophrenia from a bibliometrics perspective. In recent years, NIRS has shown unique advantages in the auxiliary diagnosis of schizophrenia, and the introduction of bibliometrics has provided a macro perspective for research in this field. Despite the opportunities brought about by these technological developments, remaining challenges require multidisciplinary approach to devise a reliable and accurate diagnosis system for schizophrenia.

Analysis of potential human accumulation differences and mechanisms of environmental new flame retardants: Based on in vitro experiments and theoretical calculations.

Hundreds of new flame retardants (NFRs) are widely used, causing environmental pollution and threating human health. In this study, based on the interaction of NFRs and human serum albumin (HSA), we assessed the differences in potential human accumulation of 8 NFRs including 1,2-Dibromo-4-(1,2-dibromoethyl)cyclohexane (TBECH), tetrabromobisphenol A bis(dibromopropyl ether) (TBBPA-DBPE), 2,4,6-tribromophenol (TBP), pentabromophenol (PBP), tri-n-butyl phosphate (TnBP), triphenyl phosphate (TPP), Tri(2-chloroethyl) phosphate (TCEP), and Tri(1,3-dichloro-2-propyl) phosphate (TDCP). All NFRs could bind to HSA and cause slight damage to its structure, suggesting their potential human accumulation ability.

Artificial biomarker-based feedback-regulated personalized and precise thrombolysis with lower hemorrhagic risk.

The body weight-based thrombolytic medication strategy in clinical trials shows critical defects in recanalization rate and post-thrombolysis hemorrhage. Methods for perceiving thrombi heterogeneity of thrombolysis resistance is urgently needed for precise thrombolysis. Here, we revealed the relationship between the thrombin heterogeneity and the thrombolysis resistance in thrombi and created an artificial biomarker-based nano-patrol system with robotic functional logic to perceive and report the thrombolysis resistance of thrombi.

Loss of Kmt2c or Kmt2d primes urothelium for tumorigenesis and redistributes KMT2A-menin to bivalent promoters.

Members of the KMT2C/D-KDM6A complex are recurrently mutated in urothelial carcinoma and in histologically normal urothelium. Here, using genetically engineered mouse models, we demonstrate that Kmt2c/d knockout in the urothelium led to impaired differentiation, augmented responses to growth and inflammatory stimuli and sensitization to oncogenic transformation by carcinogen and oncogenes. Mechanistically, KMT2D localized to active enhancers and CpG-poor promoters that preferentially regulate the urothelial lineage program and Kmt2c/d knockout led to diminished H3K4me1, H3K27ac and nascent RNA transcription at these sites, which leads to impaired differentiation.

Development of a Novel Colorimetric pH Biosensor Based on A-Motif Structures for Rapid Food Freshness Monitoring and Spoilage Detection.

Accurate methods for assessing food freshness through colorimetric pH response play a critical role in determining food spoilage and ensuring food quality standards. This study introduces a novel unlabeled DNA sequence, poly-dA, designed to exploit the colorimetric properties of both the single strand and the fold-back A-motif structure in conjunction with gold nanoparticles (AuNPs) under varying pH conditions. When exposed to storage temperatures of 4 °C and 25 °C, the color variations in the AuNP solution, influenced by pH level changes in mutton and sea bass samples' different storage periods, are easily discernible to the naked eye within a minute.

Lyophilized T Cell Reference Materials with Quantified Proportions of Subtypes.

The accurate quantification of T cell subtypes and their proportions is of great significance in cell-based biomanufacturing, diagnosis, and advanced therapy. The development and application of a cell reference material (RM) provide a solid foundation for reliable and consistent T cell quantification worldwide. However, creating a cell RM that is both accurate and practical remains a challenge.

Enhancing efficiency and control in DNA hydrogel synthesis: A dual rolling circle amplification approach and parameter optimization study.

DNA hydrogels are a focus of current research in the realm of cutting-edge functional biomaterials. Rolling circle amplification (RCA) technology has surfaced as a flexible approach for producing functional DNA hydrogels in a one-pot manner, owing to its effectiveness and ease of use. This study introduces a simple dual RCA approach for producing DNA hydrogels.

Patient-controlled analgesia with hydromorphone treatment for advanced colon cancer with severe pain in an older adult patient: a case report and literature review.

Background: Unrelieved cancer pain can seriously reduce patients' quality of life. Hydromorphone based patient-controlled analgesia (PCA) is widely used in surgery. In recent years, it has also gained attention in the field of cancer pain.

A Strategy Involving Microporous Microneedles Integrated with CAR-TREM2-Macrophages for Scar Management by Regulating Fibrotic Microenvironment.

Dipeptidyl peptidase 4 (DPP4) positive fibroblasts play a pivotal role in scar development following skin injury. Heterogeneous vascular endothelial cells (ECs) within scarred areas retain the capacity to drive tissue regeneration and repair. Simultaneously, TREM2 macrophages play a crucial role in the progression and resolution of fibrosis by engaging in mutual regulation with ECs.

MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor.

Purpose: Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive subtype of soft-tissue sarcoma with a high propensity to metastasize and extremely limited treatment options. Loss of the RAS-GAP NF1 leads to sustained RAF/MEK/ERK signaling in MPNST. However, single-agent MEK inhibitors (MEKi) have failed to elicit a sustained inhibition of the MAPK signaling pathway in MPNST.

Effects of transcranial magnetic stimulation on sleep structure and quality in children with autism.

Introduction: Sleep disorders are common in children with autism spectrum disorder (ASD). Transcranial magnetic stimulation (TMS) can influence the excitability of neuronal cells in stimulated areas, leading to improvements in sleep and other autistic symptoms. However, studies on clinical mechanisms of TMS in treating sleep disorders associated with ASD are limited.

Association between composite dietary antioxidant and bone mineral density in children and adolescents aged 8-19 years: findings from NHANES.

Dietary antioxidants may have beneficial effects on bone health, but it remains uncertain in children and adolescents. This study investigates the association of composite dietary antioxidant index (CDAI) with bone mineral density (BMD) in children and adolescents aged 8-19 years from the National Health and Nutrition Examination Survey (NHANES) 2007-2010. The study assessed the relationship between CDAI and BMD in 2994 individuals aged 8-19 years (average age 13.

Triblock PolyA-Mediated Protein Biosensor Based on a Size-Matching Proximity Hybridization Analysis.

The antibodies in the natural biological world utilize bivalency/multivalency to achieve a higher affinity for antigen capture. However, mimicking this mechanism on the electrochemical sensing interface and enhancing biological affinity through precise spatial arrangement of bivalent aptamer probes still pose a challenge. In this study, we have developed a novel self-assembly layer (SAM) incorporating triblock polyA DNA to enable accurate organization of the aptamer probes on the interface, constructing a "lock-and-key-like" proximity hybridization assay (PHA) biosensor.

Construction of 3D-Printed Sodium Alginate/Chitosan/Halloysite Nanotube Composites as Adsorbents of Methylene Blue.

In this study, sodium alginate/chitosan/halloysite nanotube composites were prepared by three-dimensional printing and characterized in terms of morphology, viscosity, thermal properties, and methylene blue (MB) adsorption performance. The high specific surface area and extensively microporous structure of these composites allowed for effective MB removal from wastewater; specifically, a removal efficiency of 80% was obtained after a 60 min treatment at an adsorbent loading of 1 g L and an MB concentration of 80 mg L, while the maximum MB adsorption capacity equaled 376.3 mg g.

Formation of brominated and nitrated byproducts during unactivated peroxymonosulfate oxidation of phenol.

Brominated and nitrated byproducts generated from bromide (Br) and nitrite (NO), respectively, by sulfate radical (SO) oxidation have raised increasing concern. However, little is known about the concurrent generation of brominated and nitrated byproducts in the unactivated peroxymonosulfate (PMS) oxidation process. This study revealed that Br can facilitate the transformation of NO to nitrated byproducts during unactivated PMS oxidation of phenol.

Homologous Overexpression of Tyrosinase in and Its Application in Glycinin Cross-Linking.

Tyrosinase is capable of oxidizing tyrosine residues in proteins, leading to intermolecular protein cross-linking, which could modify the protein network of food and improve the texture of food. To obtain the recombinant tyrosinase with microbial cell factory instead of isolation tyrosinase from the mushroom , a TYR expression cassette was constructed in this study. The expression cassette was electroporated into Rut-C30 and integrated into its genome, resulting in a recombinant strain C30-TYR.

Calibration method of the right-angle error of a hollow corner-cube retroreflector based on an independent autocollimator.

Hollow corner-cube retroreflectors (HCCRs) are an essential reflection component of next-generation lunar laser-ranging technology. The verticality among the three reflectors, known as the right-angle error, is a critical parameter that affects the emission performance, and thus, should be correctly measured and calibrated. However, conventional methods measure the three right-angle errors separately, which can induce error superposition during the measurement process.

Sensory Determination of Peach and Nectarine Germplasms with Instrumental Analysis.

The flavour and mouthfeel of peaches are crucial qualities of peach germplasm resources that significantly influence consumer preferences. In this study, we utilized 212 peach germplasm resources from the Nanjing Peach Resource Repository, National Fruit Germplasm facility, Jiangsu Academy of Agricultural Sciences as materials for sensory analysis, electronic nose analysis, and composition analysis via high-performance liquid chromatography (HPLC). In the sensory analysis, we divided 212 peach germplasms into three clusters based on hierarchical cluster analysis (d = 5).