Adaptative responses of Neurospora crassa by histidine kinases upon the attack of the arthropod Sinella curviseta.

Histidine kinases (HKs) are important sensor proteins in fungi and play an essential role in environmental adaptation. However, the mechanisms by which fungi sense and respond to fungivores attack via HKs are not fully understood. In this study, we utilized Neurospora crassa to investigate the involvement of HKs in responding to fungivores attack.

Late Life Cognitive Function Trajectory Among the Chinese Oldest-Old Population-A Machine Learning Approach.

Informed by the biopsychosocial framework, our study uses the Chinese Longitudinal Healthy Longevity Survey (CLHLS) dataset to examine cognitive function trajectories among the oldest-old (80+). Employing K-means clustering, we identified two latent groups: High Stability (HS) and Low Stability (LS). The HS group maintained satisfactory cognitive function, while the LS group exhibited consistently low function.

Palladium-catalyzed cascade cyclization of allenamide with 2-iodoanilines to access functionalized indoloquinolines.

A novel and efficient palladium-catalyzed cascade cyclization to indoloquinoline derivatives in one pot has been developed by using allenamide derivatives and 2-iodoanilines as the key building blocks. The process involved two cyclizations: intramolecular cyclization/π-allylic substitution and intramolecular 6- Heck cyclization. Furthermore, dihydrobenzofuro[2,3-]quinoline derivatives could also be achieved this strategy using allenyl ethers instead of allenamides.

Acid Water-ground Nano-realgar Is Superior to Crude Realgar in Promoting Apoptosis of MCF-7 Breast Cancer Cells.

Objective: Realgar is a traditional mineral Chinese medicine with antitumor effects, but it has high toxicity and low efficacy in its crude form. The purpose of this study was to optimize realgar to increase its efficacy and therapeutic potential.

Methods: Crude realgar (CR) was mechanically ground to obtain nano-realgar (NR), and then nano-realgar processed products (NRPPs) were obtained using three different traditional Chinese medicine processing methods: grinding in water, acid water, and alkali water, respectively.

Early Active Rehabilitation Treatment for a Patient with a Stable Type of Fifth Metatarsal Base Fracture: a Case Report.

In China, the stable type of fifth metatarsal base fracture is usually treated by rehabilitation methods after the limbs have been fixed for approximately 4 weeks. A 37-year-old woman fractured her fifth metatarsal base, with a stable fracture type. From the second day of the fracture onward, she agreed to participate in rehabilitative treatment that did not involve surgery or long-term fixation.

Gender differences in trajectories of mental health symptoms among Chinese earthquake survivors.

Background: Posttraumatic stress symptoms and depressive symptoms are prevalent after natural disasters. However, in a Chinese trauma context, little research examined the long-term trajectories of these two symptoms with a gender perspective.

Methods: Data came from an 8-year longitudinal survey of 3522 Wenchuan earthquake adult survivors.

Total flavone extract from Ampelopsis megalophylla induces apoptosis in the MCF‑7 cell line.

Ampelopsis megalophylla has been found to demonstrate anticancer activities in human cancer cells; however, the effect of total flavone extract (TFE), commonly used in Traditional Chinese Medicine, remains unclear. Furthermore, there is limited information on its effects on breast cancer cell lines. The present study aimed to investigate the inhibitory effects of TFE in different human cancer cell lines.

Attitudes toward aging, social support and depression among older adults: Difference by urban and rural areas in China.

Background: The specific impacts of attitudes toward aging on depressive symptoms have not been widely reported in previous studies in China.

Objectives: The aim is to examine the associations between attitudes toward aging, perceived social support, and depressive symptoms among older adults stratified by rural and urban dwelling.

Methods: This study used a cross-sectional data including 7209 participants, among which 64.

The Association Between Ethnic Identity and Non-Medical Prescription Drug Use Among A Sample of College Students: Does a Sense of Ethnic Belonging Matter?

Background: National data demonstrate significant differences in non-medical prescription drug (NMPD) use, with Whites seeming to be more likely to use compared to non-Whites. College students also appear to be at an increased risk for NMPD use.

Objectives: This study examines NMPD use using a component of social identity theory.

Types of integration and depressive symptoms: A latent class analysis on the resettled population for the Three Gorges dam project, China.

Focusing on China's Three Gorges Project (TGP)-Induced Resettlement, the largest scale resettlement induced by a single development project, this study aims to investigate different types of integration patterns among the TGP re-settlers and how modes of integration associate with depressive symptoms. Using Latent Class Analysis, we analyzed survey data on 407 TGP re-settlers. We detected three integration patterns among these re-settlers: the fully integrated (68%), the culturally and economically integrated (21%) and the unintegrated (11%).

Norepinephrine induces the expression of interleukin-6 via β-adrenoreceptor-NAD(P)H oxidase system -NF-κB dependent signal pathway in U937 macrophages.

Atherosclerosis is an inflammatory disease in the vessel wall. IL-6 is a mediator of inflammation and a major alarm hormone signaling tissue damage and infection to the body's host defense system, in particular to the liver, where it induces the synthesis of acute phase plasma proteins. Although Norepinephrine (NE) can stimulate the vascular cells to produce IL-6, it is unknown whether NE induces IL-6 expression in macrophages.

Are Recent Immigrants Larger than Earlier Ones at Their Arrival? Cohort Variation in Initial BMI among US Immigrants, 1989-2011.

Studies have reported that newly-arrived immigrants to the US often have better health outcomes, including lower body mass index (BMI) than established ones. This study tests the hypothesis about variation in initial BMI among immigrants who have come to the US during different time periods. Using 1989-2011 data from NHIS, we found that recent immigrants in general were larger at their time of arrival than the earlier ones.

Unmet expectations of adjustment and depressive symptoms among people with chronic traumatic spinal cord injury.

Objective: We attempted to gain a better understanding of overall adjustment among people with chronic traumatic spinal cord injury (TSCI) by identifying participants who experienced unmet expectations of adjustment to TSCI. We also examined the relationship between unmet expectations and depressive symptoms.

Method: This was a prospective cohort study.

Fundamental resource dis/advantages, youth health and adult educational outcomes.

Recent studies find lasting effects of poor youth health on educational attainment but use young samples and narrow life course windows of observation to explore outcomes. We apply a life course framework to three sets of Health and Retirement Study birth cohorts to examine early health status effects on education and skills attainment measured late in life. The older cohorts that we study were the earliest recipients of U.

English fluency of the US immigrants: Assimilation effects, cohort variations, and periodical changes.

Using 1% Public-Use Microdata Samples (PUMSs) of the 1980, 1990, and 2000 census and the 2010 American Community Survey (ACS), this study evaluates three simultaneous longitudinal trends in immigrants' English fluency: the assimilation process, variations across arrival cohorts, and periodical changes. The key findings include that the declining initial English fluency among new immigrants reported in a previous study based on 1980 and 1990 data (Carliner, 2000) was reversed in the 1990s and 2000s. Immigrants who arrived during the 2000s have the highest level of English fluency at the year of entry among all cohorts.

Project-induced displacement, secondary stressors, and health.

It has been estimated that about 15 million people are displaced by development projects around the world each year. Despite the magnitude of people affected, research on the health and other impacts of project-induced displacement is rare. This study extends existing knowledge by exploring the short-term health impact of a large scale population displacement resulting from China's Three Gorges Dam Project.

Unmet Expectations and Symptoms of Depression among the Three Gorges Project Resettlers.

To successfully resettle 1.27 million Chinese for the construction of the Three Gorges Project (TGP), the Chinese government employed a new re-resettlement policy which emphasizes infrastructural development of the resettlement sites to assure resettlers a sustainable livelihood following resettlement. Unfortunately, many benefits the policy promised have not materialized.

Project-induced migration and depression: a panel analysis.

The study examines the mental health consequences of involuntary migration resulting from the world's largest dam project in China. Past claims of a causal link between migration and mental health are inconclusive because they have been based mainly on retrospective data and, therefore, are plagued by a plethora of methodological problems. This study addresses these problems by analyzing the pre- and post-migration changes in depression measured by the CES-D scale with data collected using face-to-face interviews from a sample (n=1530 for the initial survey and 1070 for the follow-up) consisting of both migrants and non-migrants.

Improving the prediction of medication compliance: the example of bisphosphonates for osteoporosis.

Introduction: Administrative claims data have a limited ability to identify persons with high compliance to oral bisphosphonates. We tested whether adding information on compliance with other drugs used to treat chronic, asymptomatic conditions would improve the predictive ability of administrative data to identify adherent individuals.

Methods: Using data from a large, US healthcare organization, we identified new bisphosphonate users and their 1-year compliance to oral bisphosphonates, quantified by the Medication Possession Ratio (MPR).

Identification and validation of vertebral compression fractures using administrative claims data.

Introduction: Vertebral compression fractures (VCFs) are the most common type of osteoporotic fracture. Administrative claims data might be useful to identify VCFs, but this approach to case finding has received limited evaluation.

Methods: Using the administrative claims databases of a large regional US health care organization, we identified adults with a claim with a VCF diagnosis code from January 2003 to June 2004 and excluded persons with malignancy.

Chemiluminescence determination of barbituric acid using Ru(phen)(3)(2+)-Ce(IV) system.

A chemiluminescence (CL) method for the determination of barbituric acid (BA) was proposed, which is based on the enhancement of BA to the CL intensity of Tris-(1,10-phenanthroline)ruthenium(II) (Ru(phen)(3)(2+))-cerium(IV) (Ce(IV)) system. The concentration of BA is proportional to the CL intensity in the range of 5.0 x 10(-3)-2.

Anticipation of migration and psychological stress and the Three Gorges Dam project, China.

Findings from a prospective study of project-induced migration in China's Three Gorges Dam project are reported. The study tests the hypotheses that anticipation of involuntary migration is stressful and that the harmful effects are partially mediated and moderated by the resources migrants possess. Using data collected from a sample of designated migrants (n=975) who will be forced to relocate because they live in an area, which will be flooded once the Three Gorges project is completed, and non-migrants (n=555) in the same region, our analysis indicates that anticipation of involuntary migration is a robust predictor of mental distress.

Chemiluminescence detection of isoniazid using Ru(phen)3(2+)-isoniazid-Ce(IV) system.

In our experiment, it was observed that isoniazid could enhance the chemiluminescence (CL) emission of tris-(1,10-phenanthroline)ruthenium(II) (Ru(phen)3(2+))-cerium(IV) (Ce(IV)) system and this enhancement effect was dependent on the concentration of isoniazid, based on which, a novel CL system was established for the detection of isoniazid. Under the optimum experimental conditions, the dynamic range and detection limit are 7.0 x 10(-2) to 6.