Anti-toll-like receptor 2 antibody ameliorates hepatic injury, inflammation, fibrosis and steatosis in obesity-related metabolic disorder rats via regulating MAPK and NF-κB pathways.

Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide, which includes a spectrum of histological liver changes. Non-alcoholic steatohepatitis (NASH) is considered to be the progressive subtype of NAFLD, which is characterized by lobular inflammation and cellular ballooning on the basis of steatosis. There is a critical need to develop novel and effective therapeutic approaches for NAFLD/NASH.

Single Heterocyclic Compounds as Monoamine Oxidase Inhibitors: From Past to Present.

Inhibitors of monoamine oxidase (MAO) have shown therapeutic values in a variety of neurodegenerative diseases such as depression, Parkinson's disease and Alzheimer's disease. Heterocyclic compounds exhibit a broad spectrum of biological activities and vital leading compounds for the development of chemical drugs. Herein, we focus on the synthesis and screening of novel single heterocyclic derivatives with MAO inhibitory activities during the past decade.

Correlation study of venous thromboembolism with SAA, IL-1, and TNF-a levels and gene polymorphisms in Chinese population.

Background: The relationship between inflammation and venous thromboembolism (VTE) has not been fully elucidated.

Methods: Based on our previous studies, we detected the plasma levels of serum amyloid A protein (SAA), interleukin-1 (IL-1), and tumor necrosis factor-a (TNF-a) and their 8 gene polymorphisms by ELISA and a multiplex ligation detection reaction (iMLDR) method in 284 patients with VTE and 268 healthy controls.

Results: Levels of SAA (P=0.

Breakfast prevalence of medical students is higher than students from nonmedical faculties in Inner Mongolia Medical University.

Background: Skipping breakfast is becoming common worldwide. Our previous studies showed that the breakfast prevalence was relatively low.

Methods: In three cross-sectional studies, breakfast prevalence in various populations in Inner Mongolia Medical University campus in 2011, 2013 and 2017 was investigated.

Interpretation of the development of neoadjuvant therapy for gastric cancer based on the vicissitudes of the NCCN guidelines.

Gastric cancer is one of the most common digestive system tumors in China, and locally advanced gastric cancer (LAGC) accounts for a high proportion of newly diagnosed cases. Although surgery is the main treatment for gastric cancer, surgical excision alone cannot achieve satisfactory outcomes in LAGC patients. Neoadjuvant therapy (NAT) has gradually become the standard treatment for patients with LAGC, and this treatment can not only achieve tumor downstaging and improve surgical rate and the R0 resection rate, but it also significantly improves the long-term prognosis of patients.

The downregulation of miR-519a predicts poor prognosis and contributes to tumor progression in gastric cancer.

Introduction: MicroRNAs (miRNAs) have been demonstrated to be involved in the pathogenesis of various human cancers. However, the role of microRNA-519a (miR-519a) in gastric cancer (GC) remains unclear. This study aimed to investigate the clinical value and biological function of miR-519a in GC.

Regulation of calcium pump through Notch/Jagged/Hes signaling pathway in canine model of chronic atrial fibrillation.

Objective: Using a canine model of atrial fibrillation (AF) induced by chronic pacing of left atrial fibrillation, the present study aimed to investigate the protein expression and content change of Notch-1 and its downstream target genes including Hes1, Jagged1, and SERCA2a in the atrial myocardium of canines with chronic AF. Furthermore, the correlation between Notch-1/Hes1/Jagged1 and the SERCA2a calcium pump was also analyzed.

Methods: Ten healthy Beagle dogs including both males and females, aged 7-9 years were randomly divided into a sham group (n = 5) and AF group (n = 5).

Prevalence of peripheral neuropathy in patients with diabetes: A systematic review and meta-analysis.

Aims: We aimed to determine pooled prevalence of diabetic peripheral neuropathy (DPN) in patients with diabetes and to explore the impacts of research variables on prevalence estimates.

Methods: A systematic search was performed in PubMed, EMBASE, The Cochrane Library and Scopus from onset up to July 2018 to identify articles investigating the prevalence of DPN. Random-effects models were used to calculate the pooled prevalence of DPN.

Slow magnetic relaxation in Co-Ln heterodinuclear complexes achieved through a functionalized nitronyl nitroxide biradical.

A new nitronyl nitroxide biradical ligand NITPh-PyPzbis (5-(3-(2-pyridinyl)-1H-pyrazol-1-yl)-1,3-bis(1'-oxyl-3'-oxido-4',4',5',5'-tetramethyl-4,5-hydro-1H-imidazol-2-yl)benzene) has been successfully applied for constructing a 3d-4f Co-Ln system, giving rise to a family of novel hetero-tri-spin complexes, namely, [LnCo(hfac)(NITPh-PyPzbis)]·CHCl (LnCo = YCo 1, GdCo 2, TbCo 3, DyCo 4, and HoCo 5; hfac = hexafluoroacetylacetonate). In these hetero-tri-spin complexes, the NITPh-PyPzbis biradical chelates one Ln and one Co simultaneously by means of its adjacent aminoxyl moieties and two N donors from the 3-(2-pyridinyl)-1H-pyrazol-1-yl unit, respectively, realizing the unique biradical-Co-Ln heterodinuclear structure. Direct-current magnetic susceptibility investigations show that antiferromagnetic coupling is predominant in the YCo derivative, while the leading magnetic interaction in the GdCo analogue is ferromagnetic.

Designing Multicoordinating Nitronyl Nitroxide Radical Toward Multinuclear Lanthanide Aggregates.

Profiting from a multicoordinating nitronyl nitroxide radical, i.e. a functionalized nitronyl nitroxide biradical ligand, a family of novel tetranuclear lanthanide complexes, formulated as [RE(hfac)(NITPhO-3Pybis)] (RE = Gd , Tb , Dy , Ho , and Y ; NITPhO-3Pybis = 5-(3-pyridinyloxy)-1,3-bis(1'-oxyl-3'-oxido-4',4',5',5'-tetramethyl-4,5-hydro-1-imidazol-2-yl)benzene; hfac = hexafluoroacetylacetonate) were successfully constructed and characterized.

Effect of the frying process on the properties of gluten protein of you-tiao.

Wheat is one of the most important grains in cereal products. Gluten protein is an important component of wheat and plays an important role in the human diet. The variations of gluten protein in you-tiao were investigated in this study during frying, with a view toward a theoretical basis for the improvement of processing methods and quality in you-tiao.

Respiratory failure and macrophage activation syndrome as an onset of systemic lupus erythematosus: A case report.

Background: Macrophage activation syndrome (MAS) is defined as a specific secondary hemophagocytic lymphohistiocytosis that refers particularly to those triggered by autoimmune diseases. MAS is a rare and highly lethal complication of systemic lupus erythematosus (SLE), which can be associated with, or mimic, disease flare. However, the data regarding the clinical course, management and outcome of SLE with MAS is limited, especially in adults.

Downregulation of miR-519a Predicts Poor Prognosis and Contributes to Tumor Progression in Gastric Cancer.

Introduction: MicroRNAs (miRNAs) have been demonstrated to be involved in the pathogenesis of various human cancers. However, the role of microRNA-519a (miR-519a) in gastric cancer (GC) remains unclear. This study aimed to investigate the clinical value and biological function of miR-519a in GC.

Bioinformatics analysis of LINC00426 expression in lung cancer and its correlation with patients' prognosis.

Background: To investigate the expression of long noncoding RNA (lncRNA) LINC00426 (long intergenic nonprotein coding RNA 426) in non-small cell lung cancer (NSCLC) patients and its correlation with their prognosis.

Methods: The expression of long noncoding RNA LINC00426 of non-small cell lung cancer (NSCLC) in The Cancer Genome Atlas (TCGA) database was screened. According to the expression level of LINC00426 in tumor tissue of NSCLC patients, the patients were divided into high and low LINC00426 expression groups.

The effects of climate and catchment characteristic change on streamflow in a typical tributary of the Yellow River.

Hydrological cycle changes that occur due to a changing environment is a hot topic in the field of hydrological science. It is of great practical significance to study the response mechanism of hydrological process change for future water resources planning and management. In this study, the effects of climate and watershed characteristic change on the streamflow in a typical tributary of the Yellow River (the Fen River watershed) are studied based on the Budyko hypothesis.

Heterometallic Ln-Cu complexes derived from a phenyl pyrimidyl substituted nitronyl nitroxide biradical.

Utilizing a novel nitronyl nitroxide biradical bisNITPhPyrim involving a pyrimidine group ([5-(5-pyrimidyl)-1,3-bis(1'-oxyl-3'-oxido-4',4',5',5'-tetramethyl-4,5-hydro-1H-imidazol-2-yl)]benzene), three heterometallic Ln-Cu complexes with formulas [Ln(hfac)Cu(hfac)(bisNITPhPyrim)] (Ln = Gd 1, Tb 2, and Dy 3; hfac = hexafluoroacetylacetonate) have been achieved. In these complexes, the Cu ions are linked by N atoms of pyrimidine rings of bisNITPhPyrim radicals to form a one-dimensional chain structure, whereas each Ln ion is chelated with two neighboring NO groups of two NIT moieties of the radical. Magnetic studies reveal the presence of ferromagnetic interactions between the Gd ion and coordinated NO groups, and between the pyrimidine-bridged copper(ii) spins, which are quantified by a magnetic model, giving J = 4.

Modification, Antitumor Activity, and Targeted PPARγ Study of 18β-Glycyrrhetinic Acid, an Important Active Ingredient of Licorice.

Licorice is a traditional Chinese medicine, which is often used as sweetener and cosmetic ingredients in food and pharmaceutical industries. Among them, glycyrrhetic acid is one of the most important agents. Studies have shown that glycyrrhetic acid exhibited antitumor activities as PPARγ agonist.

Acute Deletion of METTL14 in β-Cells of Adult Mice Results in Glucose Intolerance.

N6-Methyladenosine (m6A) is the most common and abundant mRNA modification that involves regulating the RNA metabolism. However, the role of m6A in regulating the β-cell function is unclear. Methyltransferase-like 14 (METTL14) is a key component of the m6A methyltransferase complex.

Arabidopsis FHY3 and FAR1 Regulate the Balance between Growth and Defense Responses under Shade Conditions.

Increasing crop yield per unit of area can be achieved by increasing planting density. However, high-density planting could trigger shade avoidance responses, which cause exaggerated growth and increased susceptibility to various diseases. Previous studies have shown that the rapid elongation of plants under shade (i.

[Predictive Factors of Early Weight Loss after Laparoscopic Sleeve Gastrectomy].

Objective To explore the clinical factors that can be used to predict the early weight loss after laparoscopic sleeve gastrectomy(LSG).Methods The clinical data of 64 obese patients undergoing LSG in Peking Union Medical College Hospital from August 2015 to January 2018 were retrospectively analyzed.We analyzed the relationship between different clinical factors and early weight loss,determined the independent predictors based on models,and estimated their test power by using the receiver operating characteristic(ROC)curves.

Construction of rGO wrapping CuO/ZnO heterostructure photocatalyst for PNP and PAM degradation.

Copper and zinc composite oxides (CuO/ZnO) were synthesized by an impregnation-reduction-air oxidation method. A series of CuO/ZnO/rGO ternary composites were prepared by coupling with graphene oxide (GO) with different mass fractions in a solvothermal reaction system. The microscopic morphology, crystal structure, and optical characteristics of the photocatalysts were characterized.

Post-transcriptional regulation of Ghd7 protein stability by phytochrome and OsGI in photoperiodic control of flowering in rice.

Rice (Oryza sativa) is a facultative short-day (SD) plant, flowering early under SD and late under long-day (LD) conditions. Ghd7 is a major regulator of flowering time in rice, which strongly delays flowering under LD. Induction of Ghd7 expression by phytochromes has been shown to contribute to photoperiodic regulation of flowering in rice.

[Role of PPAR-γ-regulated autophagy in genistein-induced inhibition of hepatic stellate cell activation].

Objective: To investigate the inhibitory effect of genistein on activation of hepatic stellate cells (HSCs) and the role of the autophagy pathway regulated by PPAR-γ in mediating this effect.

Methods: Cultured HSC-T6 cells were exposed to different concentrations of genistein for 48 h, and HSC activation was verified by detecting the expressions of -SMA and 1(I) collagen; autophagy activation in the cells was determined by detecting the expressions of LC3-II and p62 using Western blotting. The autophagy inhibitor 3-MA was used to confirm the role of autophagy in genistein-induced inhibition of HSC activation.