Tea polyphenols, the primary bioactive constituents responsible for the various health benefits of tea, can be categorized into different subgroups according to their structural characteristics. However, the distinctions in antiviral activity among the diverse types of polyphenolic compounds remain unexplored. In the present study, fifty-eight tea polyphenols with varied structures, including eleven undescribed compounds, were isolated from Rougui Wuyi rock tea.
View Article and Find Full Text PDFNeuroinflammation is a key factor in the development of preterm white matter injury (PWMI), leading to glial cell dysfunction, arrest of oligodendrocyte maturation, and long-term neurological damage. As a potential therapeutic strategy, mesenchymal stem cells (MSCs) exhibit significant immunomodulatory and regenerative potential. Recent studies suggest that the primary mechanism of MSC action is their paracrine effects, particularly mediated by extracellular vesicles, with MSC-derived exosomes (MSC-Exos) being the key mediators.
View Article and Find Full Text PDFPharmaceutics
February 2025
Transmucosal drug products, such as aerosols, films, semisolids, suppositories, and tablets, have been developed for the treatment of various human diseases and conditions. Transmucosal drug absorption is highly influenced by the biological structures of the mucosa and the physiological environment specific to the administration route (e.g.
View Article and Find Full Text PDFCarbon fiber resin matrix composites (CFRP) are widely recognized for their exceptional properties such as high temperature resistance and high strength, making them indispensable in aerospace, automotive, and medical applications. Despite their growing use, precision machining of CFRP remains challenging. Traditional mechanical machining methods often lead to severe tool wear, matrix damage, fiber pullout, delamination, and chipping.
View Article and Find Full Text PDFMacroautophagy/autophagy is an evolutionarily conserved intracellular degradation pathway that relies on vacuoles or lysosomes. Over 40 genes have been identified in yeast cells as participants in various types of autophagy, although these genes are non-essential. While some essential genes involved in autophagy have been identified using temperature-sensitive yeast strains, systematic research on essential genes in autophagy remains lacking.
View Article and Find Full Text PDFMonitoring intracellular biomarkers is crucial for clinical disease diagnosis. However, the majority of signaling molecules face difficulties in slow transference across the cell membrane to reach intracellular detection sites, limiting their application in clinical settings. This study proposes an artificial cell-based signal probe transfer-enhanced sensing strategy to effectively detect microRNAs (miRNAs) by embedding carbon nanotubes (CNTs) in artificial cell membranes.
View Article and Find Full Text PDFBackground: Psychological safety as the key to mental health, not only affects individual happiness and quality of life but also relates to social stability and harmony. However, psychological safety is complex and multidimensional, with unclear internal structures and influencing factors and insufficient research on gender and age differences. Urban residents are living in an environment characterized by fast-paced, high-pressure, multicultural integration, and complex social relationships.
View Article and Find Full Text PDFSoc Cogn Affect Neurosci
February 2025
Social pain is a common occurrence in interpersonal interactions, yet limited research has explored the neural mechanisms underlying both social pain and social pain empathy. Existing studies often focus on the neural processes of individuals experiencing pain, referred to as "subjects," or those empathizing with them, known as "observers." This study examines the neural mechanisms involved in the process of social pain empathy from the perspective of interpersonal brain synchronization (IBS).
View Article and Find Full Text PDFThe Rpd3S histone deacetylase complex has a crucial role in genomic integrity by deacetylating transcribed nucleosomes following RNA polymerase (Pol) II passage. Cryo-EM studies highlight the importance of asymmetrical Rco1-Eaf3 dimers in nucleosome binding, yet the interaction dynamics with nucleosomal substrates alongside elongating Pol II are poorly understood. Here we demonstrate the essential function of the Rco1 N-terminal intrinsically disordered region (IDR) in modulating Pol II association, in which K/R mutations within the Rco1 IDR impair interaction of Rpd3S with the C-terminal domain (CTD) of Rpb1, without affecting nucleosome recognition or complex integrity.
View Article and Find Full Text PDFBackground/objectives: Empathy for pain enhances our ability to perceive pain and recognize potential dangers. Empathic bias occurs when members of the in-group evoke more intense empathic responses compared to out-group members. In the process of interacting with peers, children develop peer status and spontaneously form peer groups.
View Article and Find Full Text PDFPurpose: Ionizing radiation (IR) could induce damage such as DNA damage and oxidative stress. Natural products, like tea, have been demonstrated potential in mitigating these damages. However, the lack of efficient and rapid screening methods for natural products hinders their widespread application.
View Article and Find Full Text PDFObjectives: As a population at high risk for psychological distress, healthcare workers typically experience varying degrees of anxiety, depression, and burnout. Studies have found that depression and anxiety have a negative impact on the mental health domain of burnout in healthcare workers. However, little is known about the symptom-to-symptom interactions between these psychological outcomes.
View Article and Find Full Text PDFA heptasaccharide was isolated from an active fraction of Trillium tschonoskii using HILIC and high-temperature PGC chromatography methods. UHPLC-Q/TOF-MS analysis gave this oligosaccharide a degree of polymerization (DP) of 7 and MS/MS showed that it has a six-carbon aldehyde glucan structure with the possible chain 1 → 4 connected. The structure was determined by series 1D and 2D NMR in two solvents DO and DMSO‑d.
View Article and Find Full Text PDFJiaogulan herbal tea, known for its pharmacological benefits, is derived from various species within the genus Gynostemma, particular for G. pentaphyllum (GP) and G. longipes (GL).
View Article and Find Full Text PDFJ Neuroinflammation
November 2024
Dai-Bai-Jie, the root of the plant Marsdenia tenacissima from the Asclepiadaceae family, is well-known for its therapeutic effects in clearing heat, detoxifying, reducing swelling, and relieving pain as one of the most commonly used Dai medicine. Due to numerous structurally similar C21 steroidal compounds in Dai-Bai-Jie, chemical composition profiling has been substantially challenged. In this study, an offline two-dimensional chromatographic method (LC × SFC separation system) was developed to address these issues.
View Article and Find Full Text PDFAcute lung injury (ALI) is characterized by damage to the alveoli and an overabundance of inflammation. Representing a serious inflammatory condition, ALI lacks a precise treatment approach. Despite the recognized benefit impacts of Fibroblast growth factor-10 (FGF10) on ALI, the underlying mechanisms remain unelucidated.
View Article and Find Full Text PDFCCT2 serves as an aggrephagy receptor that plays a crucial role in the clearance of solid aggregates, yet the underlying molecular mechanisms by which CCT2 regulates solid aggrephagy are not fully understood. Here we report that the binding of Cct2 to Atg8 is governed by two distinct regulatory mechanisms: Atg1-mediated Cct2 phosphorylation and the interaction between Cct2 and Atg11. Atg1 phosphorylates Cct2 at Ser412 and Ser470, and disruption of these phosphorylation sites impairs solid aggrephagy by hindering Cct2-Atg8 binding.
View Article and Find Full Text PDFIn the following study, a series of new lupeol-3-carbamate derivatives were synthesized, and the structures of all the newly derived compounds were characterized. The new compounds were screened to determine their anti-proliferative activity against human lung cancer cell line A549, human liver cancer cell line HepG2, and human breast cancer cell line MCF-7. Most of the compounds were found to show better anti-proliferative activity in vitro than lupeol.
View Article and Find Full Text PDFBackground: Less attention has been paid to the pathophysiological changes in atypical asthma such as cough variant asthma (CVA) and chest tightness variant asthma (CTVA). The obstruction of large and small airways is the important component in the development of asthma. We investigated whether small airway inflammation (SAI) induced small airway dysfunction (SAD) in these atypical asthmatics.
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