Semaphorin 3A promotes the long-term persistence of human SVF-derived microvascular networks in engineered grafts.

Introduction: The stromal vascular fraction (SVF) of human adipose tissue is an attractive cell source for engineering grafts with intrinsic vascularization potential, as it is rich in vasculogenic progenitors. However, in order to maintain their functional perfusion it is important to promote the stabilization of newly assembled microvascular networks. We previously found that Semaphorin 3A (Sema3A) promotes the rapid stabilization of new blood vessels induced by VEGF overexpression in skeletal muscle.

Failure of Osseointegration of a Semiconstrained Finger Prosthesis in a Post-traumatic Metacarpophalangeal Joint Defect: A Case Report.

Case: Post-traumatic defects of the metacarpophalangeal joint (MCPj) remain challenging for hand surgeons. Restoration of stability and motion are difficult to achieve because of the complex anatomy and kinematics. The Robert Mathys (RM) semiconstrained prosthesis offers good intrinsic stability and mobility and therefore seems suitable.