Publications by authors named "Juan Salinas Ramos"
Metastases-directed stereotactic body radiotherapy in combination with targeted therapy or immunotherapy: systematic review and consensus recommendations by the EORTC-ESTRO OligoCare consortium.
Lancet Oncol
March 2023
Stereotactic body radiotherapy (SBRT) for patients with metastatic cancer, especially when characterised by a low tumour burden (ie, oligometastatic disease), receiving targeted therapy or immunotherapy has become a frequently practised and guideline-supported treatment strategy. Despite the increasing use in routine clinical practice, there is little information on the safety of combining SBRT with modern targeted therapy or immunotherapy and a paucity of high-level evidence to guide clinical management. A systematic literature review was performed to identify the toxicity profiles of combined metastases-directed SBRT and targeted therapy or immunotherapy.
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- Whole-brain radiation therapy (WBRT) and stereotactic radiosurgery (SRS) are key treatments for brain metastases, with this study focusing on the effectiveness of volumetric modulated arc therapy (VMAT-RS) in breast cancer patients.
- 18 breast cancer patients with 41 brain metastases were evaluated, revealing that HER2+ patients had significantly longer median survival times, with the cerebellum being the most common location for metastases.
- The findings indicate that VMAT-RS offers comparable survival rates to other radiosurgery methods, highlighting that patients' baseline conditions and cancer subtypes play a crucial role in influencing outcomes.
Objective: To analyze the prevalence of antiseizure medication (ASM) in patients with brain metastasis-related epilepsy (BMRE) treated with radiosurgery and the relationship between ASM and psychiatric comorbidity.
Material And Methods: This is a cross-sectional observational design study with retrospective review of medical records of all patients with brain metastases treated with volumetric modulated arc therapy radiosurgery (VMAT-RS) between 2012 and 2018 in a tertiary oncology center. We included those patients with BMRE, analyzing the clinical and demographic data, with special attention to psychiatric comorbidities and the use of ASM.
Article Synopsis
- The OPTIMAL study investigates the effectiveness of incidental irradiation of axillary lymph nodes in early-stage breast cancer patients with limited sentinel lymph node involvement, using advanced molecular techniques for better treatment standardization.
- Patients are randomly assigned to receive either comprehensive irradiation (including axillary and supraclavicular areas) or limited irradiation (only the breast and tumor bed) after conservative surgery, with the goal of demonstrating that the incidental approach is not worse regarding disease-free survival over five years.
- The study aims to address the lack of consensus in treating breast cancer patients with few affected lymph nodes and hopes that the One-Step Nucleic Acid Amplification (OSNA) technique can help identify which patients will
Background: The aim of this paper is to determine the possible association between five different profiles of immunohistochemical expression related to clinical, histopathological and immunohistochemical known prognostic value variables for breast cancer.
Material And Method: A total of 194 breast carcinoma tumour samples were studied. In this study five groups or immunohistochemical profiles were defined, based on expression of hormone receptors (oestrogen or progesterone) and/or Her2/neu (luminal-type A, luminal-type B, mixed profile, Her2/neu profile and triple-negative-type profile) and we studied whether there are differences between them with regard to clinical, histopathological and immunohistochemical variables that have a known prognostic significance.