Evaluation of γ-H2AX foci distribution among different peripheral blood mononucleated cell subtypes.

Introduction: The detection of γ-H2AX foci in peripheral blood mononucleated cells (PBMCs) has been incorporated as an early assay for biological dosimetry. However, overdispersion in the γ-H2AX foci distribution is generally reported. In a previous study from our group, it was suggested that overdispersion could be caused by the fact that when evaluating PBMCs, different cell subtypes are analyzed, and that these could differ in their radiosensitivity.

Establishment and validation of surface model for biodosimetry based on γ-H2AX foci detection.

Introduction: In the event of a radiation accident detecting γ-H2AX foci is being accepted as fast method for triage and dose assessment. However, due to their disappearance kinetics, published calibrations have been constructed at specific post-irradiation times.

Objectives: To develop a surface, or tridimensional, model to estimate doses at times not included in the calibration analysis, and to validate it.

Charge Disproportionation Triggers Bipolar Doping in FeSbSn Se Ferromagnetic Semiconductors, Enabling a Temperature-Induced Lifshitz Transition.

Ferromagnetic semiconductors (FMSs) featuring a high Curie transition temperature ( T) and a strong correlation between itinerant carriers and localized magnetic moments are of tremendous importance for the development of practical spintronic devices. The realization of such materials hinges on the ability to generate and manipulate a high density of itinerant spin-polarized carriers and the understanding of their responses to external stimuli. In this study, we demonstrate the ability to tune magnetic ordering in the p-type FMS FeSbSn Se (0 ≤ x ≤ 0.

Crystal Structure and Thermoelectric Properties of the L Lillianite Homologue PbBiSe.

PbBiSe, the selenium analogue of heyrovsyite, crystallizes in the orthorhombic space group Cmcm (#63) with a = 4.257(1) Å, b = 14.105(3) Å, and c = 32.

Management of sympathetic ophthalmia with the fluocinolone acetonide implant.

Objective: We examined whether implantation of the fluocinolone acetonide (Retisert) implant achieved control of inflammation and a reduced need for oral corticosteroids or immunosuppressives in patients with sympathetic ophthalmia (SO).

Design: Retrospective, noncomparative case series.

Participants: Eight patients with active SO.

The effect of treatment with eprosartan on pulse pressure: factors predicting response.

Background: Pulse pressure is an important cardiovascular risk factor, particularly in the elderly and in patients with isolated systolic hypertension. The differential impact of antihypertensive agents on pulse pressure is not known.

Objective: To assess the antihypertensive effect of treatment with the angiotensin II receptor blocker eprosartan on pulse pressure, and the factors influencing this effect.

[Prevalence and general features of the metabolic syndrome in the Spanish hypertensive population].

Background And Objective: Metabolic syndrome (MS) constitutes a risk factor for the development of both type 2 diabetes and cardiovascular disease. The aim of the present study was to assess the prevalence and clinical characteristics of metabolic syndrome in a sample of the hypertensive population.

Patients And Method: Cross-sectional epidemiological study in 19,039 hypertensive patients attended in primary care centres.

Effect of eprosartan on pulse pressure and blood pressure components in patients with isolated systolic hypertension.

Background: Systolic blood pressure (SBP) and pulse pressure (PP) are accurate predictors of cardiovascular events in the elderly population. In these patients, isolated systolic hypertension (ISH) is an important risk factor for cardiovascular morbidity and mortality.

Study Design: A multicentre, observational, prospective study, evaluated the effects of 16 weeks of eprosartan treatment on PP and other blood pressure (BP) parameters.

[Effect of antihypertensive therapy on pulse pressure].

Background: Pulse pressure (difference between systolic and diastolic pressure) is an important prognostic factor for cardiovascular mortality and morbidity in elderly hypertensives. However, data regarding the effect of antihypertensive treatment on pulse pressure (PP) are scarce. In the present study, we evaluate the effect of six classes of antihypertensive drugs on PP in an elderly hypertensive cohort.

Quality of life in functional dyspepsia.

Our purpose was to assess the quality of life of functional dyspepsia patients using the SF-36 generic scale and the Gastrointestinal Symptoms Rating Scale (GSRS). In all, 328 dyspeptic patients were included in a multicenter, prospective, observational study. Both scales were filled out at baseline and one and three months after a prokinetic agent was given as a single-drug therapy.