Publications by authors named "Juan S Alarcon-Aldana"
Parasporin PS2Aa1, recently renamed Mpp46Aa1, is an anti-cancer protein known for its selectivity against various human cancer cell lines. We genetically modified native PS2Aa1 to create a library of approximately 100 mutants. From this library, we selected promising mutants based on their half-maximal inhibitory concentration (IC) and sequence variations.
View Article and Find Full Text PDFParasporin 2 has cytotoxic effects against numerous colon cancer cell lines, making it a viable alternative to traditional treatments. However, its mechanism of action and receptors remain unknown. In this study, site-directed mutagenesis was used to obtain PS2Aa1 mutants with variation in domain I at positions 256 and 257.
View Article and Find Full Text PDFArticle Synopsis
- Some strains of the bacterium produce Cry toxins, known for fighting insects, but some strains create proteins with potential cancer-fighting abilities instead of insecticidal properties.
- Parasporins (PSs), a specific type of Cry protein, show selective cytotoxic activity against various cancer cell lines while sparing normal human cells, making them promising for cancer treatments.
- This review explores the classification, structures, action mechanisms, and genetic modifications of PS proteins to better understand their potential in cancer therapy.