Upregulation of HAS2 promotes glioma cell proliferation and chemoresistance via c-myc.

Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant human brain tumor. Although comprehensive therapies, including chemotherapy and radiotherapy following surgery, have shown promise in prolonging survival, the prognosis for GBM patients remains poor, with an overall survival rate of only 14.6 months.

Pan-cancer analysis reveals the potential of hyaluronate synthase as therapeutic targets in human tumors.

Hyaluronic acid (HA) is a crucial component of the extracellular matrix, and its level of accumulation is related to the progression of various malignant tumors. In this study, a pan-cancer analysis of the three enzymes called hyaluronan synthases (HAS1, HAS2, and HAS3) that produce HA was performed. The study comprehensively describes the characteristics of HAS1, HAS2, and HAS3 in cancers using public databases and tools, to identify the potential biological pathways involved at the molecular, protein, cellular, and clinical sample levels.

3D Printing Technology with Reverse Guide Design in Autogenous Tooth Transplantation: An in vitro Pictorial Report.

The success of autologous tooth transplantation depends on the activity of the periodontal ligament of the donor tooth. Its activity decreases with a longer exposure time. In order to reduce the exposure time of the donor tooth and quickly prepare the alveolar fossa highly matching with the donor tooth root, the clinical data of cone-beam CT (CBCT) was imported into Mimics 21.

Effects of cryopreservation on the biomechanical properties of dentin in cryopreserved teeth: An in-vitro study.

This study focused on the biomechanical properties and microstructural changes in dentin of teeth in different age groups after cryopreserved for different durations. Ninety third molars from three age groups (youth group, middle-age group, and elderly group), were collected and randomly divided into three groups according to freezing time at -196 °C (7 days, 30 days, and 90 days). Control group was shored at ordinary temperature.

The Complete Chloroplast Genome Sequence of : Genome Organization and Comparison with Related Species.

Turcz, a perennial herb of the Asteraceae family, is one of the horticultural and medicinal plants used for curing various diseases and is widely distributed in China and other Asian countries. It possesses antibacterial, antimetastatic, antiangiogenic, and antioxidant properties along with anticancer potential. However, the intrageneric classification and phylogenetic relationships within have long been controversial due to the lack of high-resolution molecular markers, and the complete chloroplast (cp) genome sequencing has not been reported with new evolutionary insights.

[Research on the characteristic of toluene migration and distribution in fluvoaquic soil and its simulation using STOMP model].

Frequently accidental spill of hazard materials into soil environment posed significant threats to human health and natural environment in China. In this paper, simulated nonaqueous phase liquid (NAPLs) toluene sudden spill in fluvo-aquic soil was performed in a two-dimensional tank to investigate the migration and distribution characteristics of toluene as well as its simulation through STOMP model. Visual observation showed that the horizontal expansion of toluene with concentration > 1 g x kg(-1) and > 20 g x kg(-1) were approximate 2.