Publications by authors named "Juan Ramiro Lorenzo"
TAR DNA-binding protein 43 (TDP-43) proteinopathy in brain cells is the hallmark of amyotrophic lateral sclerosis (ALS) but its cause remains elusive. Asparaginase-like-1 protein (ASRGL1) cleaves isoaspartates, which alter protein folding and susceptibility to proteolysis. ASRGL1 gene harbors a copy of the human endogenous retrovirus HML-2, whose overexpression contributes to ALS pathogenesis.
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- - Redox regulation in biology heavily involves cysteine chemistry, which can be both beneficial for protein function and harmful due to potential oxidation, affecting how proteins operate under different cellular conditions.
- - Papillomaviruses provide a unique opportunity to study protein evolution, particularly through the oncoprotein E7, which is rich in cysteine and showcases both conserved and variable properties that help understand redox-sensitive mechanisms.
- - Analysis of E7 sequences reveals that while noncanonical cysteines don't follow a clear sequence pattern, their positioning is influenced by topological constraints, suggesting a method to identify unrecognized regulatory cysteines that aren't detected through typical sequence-based approaches.