Quantum Inequalities for Quantum Black Holes.

We formulate spacetime inequalities applicable to quantum-corrected black holes to all orders of backreaction in semiclassical gravity. Namely, we propose refined versions of the quantum Penrose and reverse isoperimetric inequalities, valid for all known three-dimensional asymptotically anti-de Sitter quantum black holes. Previous proposals of the quantum Penrose inequality apply in higher dimensions but fail when applied in three dimensions beyond the perturbative regime.

Mechanisms of cell size regulation in slow-growing Escherichia coli cells: discriminating models beyond the adder.

Under ideal conditions, Escherichia coli cells divide after adding a fixed cell size, a strategy known as the adder. This concept applies to various microbes and is often explained as the division that occurs after a certain number of stages, associated with the accumulation of precursor proteins at a rate proportional to cell size. However, under poor media conditions, E.

Antimicrobial susceptibility of mastitis pathogens isolated from North American dairy cattle, 2011-2022.

A total of 10,890 bacterial isolates of Streptococcus dysgalactiae, Streptococcus uberis, Staphylococcus aureus and Escherichia coli isolated as etiological agents from dairy cows with mastitis by 29 veterinary laboratories across North America between 2011 and 2022 were tested for in vitro antimicrobial susceptibility by broth microdilution to ampicillin, cefoperazone, ceftiofur, cephalothin, erythromycin, oxacillin, penicillin-novobiocin and pirlimycin according to CLSI standards. Using available clinical breakpoints, antimicrobial resistance among S. dysgalactiae (n = 2406) was low for penicillin-novobiocin (0% resistance), ceftiofur (0.

Mechanisms of Cell Size Regulation in Slow-Growing Cells: Discriminating Models Beyond the Adder.

Under ideal conditions, cells divide after adding a fixed cell size, a strategy known as the . This concept applies to various microbes and is often explained as the division that occurs after a certain number of stages, associated with the accumulation of precursor proteins at a rate proportional to cell size. However, under poor media conditions, cells exhibit a different size regulation.

Association between clinical and surgical variables with postoperative outcomes in patients treated for intestinal obstruction for non-malignant conditions: a cross-sectional study.

Intestinal obstruction is considered a frequent surgical pathology related to previous surgical procedures. Many different factors can lead to different outcomes when surgical management is needed. Therefore, we aim to describe the factors related to morbidity and mortality in surgical management of IO in a single-center experience.

Giant squamous cell carcinoma developed on a mesh-related enterocutaneous fistula: A case report.

Introduction: Squamous cell carcinoma degeneration on enterocutaneous fistulas (EF) is infrequent. There are some reports of malignant conversion in Crohn's disease-associated fistulas. Literature about the malignant development of mesh-related EF is even more limited.

Higher-Dimensional Origin of Extended Black Hole Thermodynamics.

Holographic braneworlds are used to present a higher-dimensional origin of extended black hole thermodynamics. In this framework, classical, asymptotically anti-de Sitter black holes map to quantum black holes in one dimension less, with a conformal matter sector that backreacts on the brane geometry. Varying the brane tension alone leads to a dynamical cosmological constant on the brane, and, correspondingly, a variable pressure attributed to the brane black hole.

Retrospective validation of parkland grading scale in a Latin-American high-volume center.

Background: Increased complication rates following laparoscopic cholecystectomies have been described, likely related to surgical difficulty, anatomical variations, and gallbladder inflammation severity. Parkland Grading Scale (PGS) stratifies the severity of intraoperative findings to predict operative difficulty and complications. This study aims to validate PGS as a postoperative-outcome predictive tool, comparing its performance with Tokyo Guidelines Grading System (TGGS).

Smart pooling: AI-powered COVID-19 informative group testing.

Massive molecular testing for COVID-19 has been pointed out as fundamental to moderate the spread of the pandemic. Pooling methods can enhance testing efficiency, but they are viable only at low incidences of the disease. We propose Smart Pooling, a machine learning method that uses clinical and sociodemographic data from patients to increase the efficiency of informed Dorfman testing for COVID-19 by arranging samples into all-negative pools.

Lorentzian Threads as Gatelines and Holographic Complexity.

The continuous min flow-max cut principle is used to reformulate the "complexity=volume" conjecture using Lorentzian flows-divergenceless norm-bounded timelike vector fields whose minimum flux through a boundary subregion is equal to the volume of the homologous maximal bulk Cauchy slice. The nesting property is used to show the rate of complexity is bounded below by "conditional complexity," describing a multistep optimization with intermediate and final target states. Conceptually, discretized Lorentzian flows are interpreted in terms of threads or gatelines such that complexity is equal to the minimum number of gatelines used to prepare a conformal field theory (CFT) state by an optimal tensor network (TN) discretizing the state.

Continuous rate modeling of bacterial stochastic size dynamics.

Bacterial division is an inherently stochastic process with effects on fluctuations of protein concentration and phenotype variability. Current modeling tools for the stochastic short-term cell-size dynamics are scarce and mainly phenomenological. Here we present a general theoretical approach based on the Chapman-Kolmogorov equation incorporating continuous growth and division events as jump processes.

Slipstreaming Mother Machine: A Microfluidic Device for Single-Cell Dynamic Imaging of Yeast.

The yeast is one of the most basic model organisms for studies of aging and other phenomena such as division strategies. These organisms have been typically studied with the use of microfluidic devices to keep cells trapped while under a flow of fresh media. However, all of the existing devices trap cells mechanically, subjecting them to pressures that may affect cell physiology.

Correlation between protein concentration and bacterial cell size can reveal mechanisms of gene expression.

Classically, gene expression is modeled as a chemical process with reaction rates dependent on the concentration of the reactants (typically, DNA loci, plasmids, RNA, enzymes, etc). Other variables like cell size are in general ignored. Size dynamics can become an important variable due to the low number of many of these reactants, imperfectly symmetric cell partitioning and molecule segregation.

Unification of cell division control strategies through continuous rate models.

Recent experiments support the adder model for E. coli division control. This model posits that bacteria grow, on average, a fixed size before division.

Efficient computation of stochastic cell-size transient dynamics.

Background: How small, fast-growing bacteria ensure tight cell-size distributions remains elusive. High-throughput measurement techniques have propelled efforts to build modeling tools that help to shed light on the relationships between cell size, growth and cycle progression. Most proposed models describe cell division as a discrete map between size at birth and size at division with stochastic fluctuations assumed.

Strongly Coupled Anisotropic Gauge Theories and Holography.

We initiate a nonperturbative study of anisotropic, nonconformal, and confining gauge theories that are holographically realized in gravity by generic Einstein-axion-dilaton systems. In the vacuum, our solutions describe renormalization group flows from a conformal field theory in the UV to generic scaling solutions in the IR with generic hyperscaling violation and dynamical exponents θ and z. We formulate a generalization of the holographic c theorem to the anisotropic case.

Chaotic Strings in AdS/CFT.

Holographic theories with classical gravity duals are maximally chaotic; i.e., they saturate the universal bound on the rate of growth of chaos [J.

[Ethical dilemmas about disclosure of errors in medicine].

Since the publication of the Institute of Medicine’s report “To Err is Human: Building a Safer Health System” awareness of the importance of medical errors has increased. These are a major cause of morbidity and mortality and recent studies suggest that they can be the third leading cause of death in the United States. Difficulties have been identified by health personnel to prevent, detect and disclose to patients the occurrence of a medical error, an also to report them to the appropriate authorities.

Culturally competent approaches to diagnosing ADHD in Hispanic adults and overcoming cultural issues with patients and families.

Hispanics in the United States are a diverse population with different countries of origin and a wide range of English language proficiency, socioeconomic and immigration status, values, and traditions. Clinicians must combine what they know about treating adult ADHD in general with a culturally competent understanding of the special needs of Hispanic patients in order to provide effective and accessible treatment. Strategies to treat Hispanic adults may include clear communication during the patient's interview, assessment of comorbid conditions, and affordable treatment options.

Neural mechanisms underlying the therapeutic actions of guanfacine treatment in youth with ADHD: a pilot fMRI study.

Twenty-five youth with attention-deficit/hyperactivity disorder (ADHD) were scanned with functional magnetic resonance imaging (fMRI) while performing a Go/No-go task before and after 6-8 weeks of randomized once-daily treatment with either the α₂A-adrenergic receptor agonist guanfacine or placebo. Clinical improvement was greater for guanfacine than placebo and was differentially associated with reduced activation for guanfacine compared with placebo in the right midcingulate cortex/supplementary motor area and the left posterior cingulate cortex.