Interactive Role of Surrogate Liver Fibrosis Assessment and Insulin Resistance on the Incidence of Major Cardiovascular Events.

: The combination of easy-to-obtain validated biomarkers is interesting in the prognostic evaluation of patients at cardiovascular risk in a precision medicine scenario. The evaluation of the effect modification of insulin resistance and liver fibrosis with the Triglyceride-Glucose index (TyG) and Fibrosis-4 index (FIB4) might provide prognostic information in patients at cardiovascular risk. A retrospective cohort study was performed with 2055 patients recruited in the Vascular Metabolic CUN cohort.

Flexible, self-powered sensors for estimating human head kinematics relevant to concussions.

The present work demonstrates the development of a flexible, self-powered sensor patch that can be used to estimate angular acceleration and angular velocity, which are two essential markers for predicting concussions. The device monitors the dynamic strain experienced by the neck through a thin, polypropylene-based ferroelectret nanogenerator that produces a voltage pulse with profile proportional to strain. The intrinsic property of this device to convert mechanical input to electrical output, along with its flexibility and [Formula: see text] 100 [Formula: see text]m thickness makes it a viable and practical device to be used as a wearable patch for athletes in high-contact sports.

Piezoelectric Lateral-Extensional Mode Resonators With Reconfigurable Electrode and Resonance Mode-Switching Behavior Enabled by a VO₂ Thin-Film.

This article presents the first two-port lateral-extensional mode zinc oxide (ZnO) piezoelectric resonator with a reconfigurable bottom electrode that is enabled by embedding a vanadium dioxide (VO) thin film. The insulator-to-metal phase transition of VO is triggered by substrate heating that translates to abrupt changes in electric field patterns and piezoelectrically transduced modal vibrations, thus allowing mode-switching of piezoelectric resonators at specific frequencies. Finite element method (FEM) analysis was used to model the broadband frequency response, while frequency characteristics of the corresponding two-port resonator were measured over a temperature range between 20 °C and 95 °C with a specific focus on two resonances at 88 and 148 MHz.

VO-based micro-electro-mechanical tunable optical shutter and modulator.

VO-based MEMS tunable optical shutters are demonstrated. The design consists of a VO-based cantilever attached to a VO-based optical window with integrated resistive heaters for individual mechanical actuation of the cantilever structure, tuning of the optical properties of the window, or both. Optical transmittance measurements as a function of current for both heaters demonstrates that the developed devices can be used as analog optical shutters, where the intensity of a light beam can be tuned to any value within the range of VO phase transition.

Association of SDF1 and MMP12 with Atherosclerosis and Inflammation: Clinical and Experimental Study.

Background: Atherosclerosis is the main etiology of cardiovascular diseases (CVD), associated to systemic inflammation. Matrix metalloproteinases (MMPs) are related to atherosclerosis progression through the SDF1/CXCR4 axis promoting macrophages recruitment within the vascular wall. The goal was to assess new circulatory inflammatory markers in relation to atherosclerosis.

Design, Simulation, Fabrication, and Characterization of an Electrothermal Tip-Tilt-Piston Large Angle Micromirror for High Fill Factor Segmented Optical Arrays.

Micro-electromechanical system (MEMS) micromirrors have been in development for many years, but the ability to steer beams to angles larger than 20° remains a challenging endeavor. This paper details a MEMS micromirror device capable of achieving large motion for both tip/tilt angles and piston motion. The device consists of an electrothermal actuation assembly fabricated from a carefully patterned multilayer thin-film stack (SiO/Al/SiO) that is epoxy bonded to a 1 mm Au coated micromirror fabricated from an SOI wafer.

Electrode Effects on Flexible and Robust Polypropylene Ferroelectret Devices for Fully Integrated Energy Harvesters.

This work presents a characterization study of the electrode interface in polypropylene ferroelectret nanogenerators. An emphasis is made on the comparison of carbon nanotube fiber electrodes with traditional metallic thin film electrodes. Multiple experiments were performed on samples with the same electrode dimensions for a range of applied pressures.

Ferroelectret Nanogenerators for Loudspeaker Applications: A Comprehensive Study.

A ferroelectret nanogenerator (FENG) was recently developed as a flexible energy harvesting device with bi-directional capability between electrical and mechanical energy domains, and its use as a loudspeaker/microphone was demonstrated. Dependencies of Sound Pressure Levels (SPLs) generated by FENG due to an AC voltage stimulus, surface area, geometric shape, and addition of layers are presented here. Also, the relation between the sound output to the electrical input is studied and shown to be linear, which demonstrates that these flexible loudspeakers have low distortion within the human audible range of 20 Hz to 20 kHz.

Flexible Ferroelectret Polymer for Self-Powering Devices and Energy Storage Systems.

Applying flexible materials for energy scavenging from ambient mechanical vibrations is a clean energy solution that can help alleviate electrical power demands in portable devices and wearable electronics. This work presents fundamental studies on a flexible ferroelectret polymer with a strong piezoelectric effect and its interface with self-powered and energy storage systems. A single-layered device with a thickness of 80 μm was used for characterizing the device's output voltage, current, transferred charge, and energy conversion efficiency.

Analysis of monocitary subpopulations in relation to cardiovascular risk factors.

Introduction: Monocytes play an important role in atherosclerotic progression having both pro and anti-inflammatory effects depending on different circulating monocyte subpopulations. The objective of this study is to characterize these subpopulations and their association with cardiovascular risk factors.

Methods: Transversal study including 102 selected patients, mean age: 65 years-old (range 41-86), 69% males.

Treatment of reperfused ischemia with adipose-derived stem cells in a preclinical Swine model of myocardial infarction.

The aim of the study was to determine the long-term effect of transplantation of adipose-derived stromal cells (ADSCs) in a preclinical model of ischemia/reperfusion (I/R). I/R was induced in 28 Goettingen minipigs by 120 min of coronary artery occlusion followed by reperfusion. Nine days later, surviving animals were allocated to receive transendocardial injection of a mean of 213.