Publications by authors named "Juan Pablo Sottile"
Objective: To test the hypothesis that levosimendan increases systemic and intestinal oxygen delivery (DO(2)) and prevents intramucosal acidosis in septic shock.
Design: Prospective, controlled experimental study.
Setting: University-based research laboratory.
Article Synopsis
- Levosimendan, an inotropic and vasodilator drug, was tested in a study with anesthetized sheep to evaluate its effects during endotoxaemia, particularly on oxygen transport and hemodynamics.
- In the levosimendan group, there was a significant increase in systemic and intestinal oxygen transport compared to the endotoxin group, despite no change in stroke volume; the rise in cardiac output was attributed to a higher heart rate.
- While levosimendan prevented gut intramucosal acidosis, it also led to lower mean arterial blood pressure and increased blood lactate levels, indicating some adverse effects alongside its benefits.