Publications by authors named "Juan Mateo Flores"
Chem Biodivers
March 2023
Article Synopsis
- - The study calculates the optimized geometry and electrostatic potential of palbociclib using density functional theory to analyze its interactions with kinases.
- Molecular docking reveals that the geometry of palbociclib contributes to its hydrogen bonding with CDK4 and CDK6 kinases, suggesting its potential effectiveness against various cancers, not just myeloid leukemia.
- The results match existing literature and indicate the promiscuity of palbociclib with multiple kinases, which may provide insights into targeting resistant cancer types effectively.
