Computer model for gait assessments in Parkinson's patients using a fuzzy inference model and inertial sensors.

Patients with Parkinson's disease (PD) in the moderate and severe stages can present several walk alterations. They can show slow movements and difficulty initiating, varying, or interrupting their gait; freezing; short steps; speed changes; shuffling; little arm swing; and festinating gait. The Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) has a good reputation for uniformly evaluating motor and non-motor aspects of PD.

Reassessing blood product irradiation in haploidentical transplantation: a single-center perspective.

Objectives: The main objective was to investigate the incidence of transfusion-associated graft-versus-host disease (TA-GVHD) in patients who underwent haploidentical hematopoietic cell transplants (HCT) and received non-irradiated leukoreduced blood components. The secondary objective was to describe our leukodepletion results in blood products obtained by the filters employed at our center.

Study Design And Methods: Clinical records from 2018 to 2023 were retrospectively analyzed, along with a prospective evaluation of residual leukocytes in blood components from June to November 2023 in order to confirm effectivity of our leukodepletion method.

A Computer Method for Pronation-Supination Assessment in Parkinson's Disease Based on Latent Space Representations of Biomechanical Indicators.

One problem in the quantitative assessment of biomechanical impairments in Parkinson's disease patients is the need for scalable and adaptable computing systems. This work presents a computational method that can be used for motor evaluations of pronation-supination hand movements, as described in item 3.6 of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS).

Computer model for leg agility quantification and assessment for Parkinson's disease patients.

Parkinson's disease (PD) is a progressive disorder that affects motor regulation. The Unified Parkinson's Disease Rating Scale sponsored by the Movement Disorder Society (MDS-UPDRS) quantifies the illness progression based on clinical observations. The leg agility is an item in this scale, yet only a visual detection of the features is used, leading to subjectivity.

Rest tremor quantification based on fuzzy inference systems and wearable sensors.

Background: Currently the most consistent, widely accepted and detailed instrument to rate Parkinson's disease (PD) is the Movement Disorder Society sponsored Unified Parkinson Disease Rating Scale (MDS-UPDRS). However, the motor examination is based upon subjective human interpretation trying to capture a snapshot of PD status. Wearable sensors and machine learning have been broadly used to analyze PD motor disorder, but still most ratings and examinations lay outside MDS-UPDRS standards.

Effect of part-time cardiac catheterization facilities in patients with acute myocardial infarction.

Background: Although the easy availability of invasive cardiac care facilities is associated with an increase in their use, their influence on outcomes is not clear. We sought to investigate whether a newly available cardiac catheterization laboratory (CCL) performing percutaneous coronary intervention (PCI) on a part-time (PT) basis might improve outcomes in patients with acute myocardial infarction (AMI).

Methods: This was an observational cohort study that included all consecutive patients with AMI admitted to a secondary-level hospital in Spain before and after the PT-CCL opened in January 2006: during 1998-2005 and 2006-2014, respectively.

Microcystins from tap water could be a risk factor for liver and colorectal cancer: a risk intensified by global change.

An increasing number of people drink water from fresh water supply reservoirs. However, with the global change a lot of reservoirs become eutrophic, which facilitates the occurrence of toxin-producing cyanobacterial blooms. Microcystins (powerful hepatotoxic water-soluble heptapeptides) are the most important cyanobacterial toxins affecting humans.

[Female sex is inversely and independently associated with marked ST-segment elevation. A study in patients with ST-segment elevation acute myocardial infarction and early admission].

Introduction And Objectives: In patients with acute myocardial infarction, a number of variables in the initial ECG are useful prognostic indicators. The presence of ST-segment elevation, however, usually indicates the need for reperfusion therapy. The aims of this study were to investigate sex differences in the ECGs of patients with ST-elevation myocardial infarction (STEMI) and to look for a possible association between sex and marked ST-segment elevation.

Shellfish consumption: a major risk factor for colorectal cancer.

In the last decades, relevant efforts have been made to reduce the cancer incidence in the European Union. The prevention programmes against cancer have obtained satisfactory results except for colorectal cancer (CRC). Identification of risk factors is primordial to plan preventive strategies for CRC.