Publications by authors named "Juan Marquet Palomanes"
Survival after allogeneic transplantation according to pretransplant minimal residual disease and conditioning intensity in patients with acute myeloid leukemia.
Front Oncol
May 2024
Article Synopsis
- Pretransplant measurement of minimal residual disease (MRD) in acute myeloid leukemia (AML) patients undergoing hematopoietic stem cell transplantation (HSCT) impacts their prognosis, particularly in relation to conditioning intensity.
- * The study analyzed transplant outcomes of 118 AML patients, revealing that those with positive MRD (MRD+) before HSCT had significantly worse event-free survival (EFS) and higher relapse rates compared to those with negative MRD (MRD-).
- * Among patients treated with myeloablative conditioning (MAC), MRD- patients fared better in terms of EFS and overall survival, while those receiving reduced intensity conditioning (RIC) showed similar outcomes, regardless of MRD status.*
Patients with secondary acute myeloid leukemia undergoing allogeneic stem-cell transplant have inferior outcomes than de novo acute myeloid leukemia regardless minimal residual disease level by flow cytometry.
Hematol Oncol
October 2023
Article Synopsis
- Patients with secondary acute myeloid leukemia (s-AML) do not do as well after treatment compared to those with regular (de novo) acute myeloid leukemia (AML).
- A study compared 58 s-AML patients with 52 de novo AML patients who had a stem-cell transplant.
- The results showed that s-AML patients had a higher chance of health problems and dying after the transplant, especially if they weren’t in complete remission before the procedure.
Backgound: In the workup of follicular lymphoma (FL), bone marrow biopsy (BMB) assessment is a key component of FLIPI and FLIPI2, the most widely used outcome scores. During the previous decade, several studies explored the role of FDG-PET/CT for detecting nodal and extranodal disease, with only one large study comparing both techniques.
Methods: The aim of our study was to evaluate the diagnostic accuracy and the prognostic impact of both procedures in a retrospective cohort of 299 FL patients with both tests performed at diagnosis.
COVID-19 is affecting many countries all around the world. Unfortunately, no treatment has already been approved for the management of patients infected by SARS-CoV-2. It seems that SARS-CoV-2 can induce the activation of an exaggerated immune response against itself according to different mechanisms that are not really well known.
View Article and Find Full Text PDFSystemic nocardiosis in acquired aplastic anaemia: Report of 2 cases.
Enferm Infecc Microbiol Clin (Engl Ed)
January 2021
Diffuse follicular lymphoma (FL) variant is a rare condition that shows distinctive clinical, morphological, immunophenotypic, and molecular features that distinguish it from classical FL. Diffuse FL variant is characterized by a predominantly diffuse growth pattern, absence of the t (14;18) IGH/BCL2 translocation, CD23 expression, and presence of 1p36 deletion. Gene mutations involving STAT6 have been reported, with nuclear expression of STAT6 and phosphorylated STAT6 detected by immunohistochemistry.
View Article and Find Full Text PDFBackground: The significance of discrepant findings between histology (BMB) and flow cytometry (FC) in bone marrow (BM) examination at diffuse large B-cell lymphoma (DLBCL) diagnosis is uncertain.
Methods: We performed a 5-year retrospective single-center study of patients diagnosed by DLBCL not otherwise specified (n = 82), divided into three groups according to BM infiltration at diagnosis: BMB-/FC- (75.6%), BMB+/FC+ (13.