The unique metabolic and lipid profiles of patients with severe COVID-19 compared to severe community-acquired pneumonia: a potential prognostic and therapeutic target.

Background: Compare the changes and differences in metabolome and lipidome profiles among severe COVID-19 and CAP patients with ARF to identify biomarkers that could be used for personalized diagnosis, prognosis, and treatment.

Research Design And Methods: Plasma samples were taken at hospital admission (baseline) and on the 5 day of hospitalization (follow-up) and examined by RP-LC-QTOF-MS and HILIC-LC-QTOF-MS.

Results: 127 patients, 17 with CAP and 110 with COVID-19, were included.

The potential impact of PCV-13, PCV-15 and PCV-20 vaccines in Colombia.

Purpose: To provide information about which pneumococcal vaccine could have greater coverage in Colombia.

Methods: This is a retrospective analysis of patients diagnosed with invasive pneumococcal disease (IPD) between 2015 and 2019 in Bogotá, Colombia. We compared the theoretical serotype coverage of the available anti-pneumococcal vaccines (i.