Complete Spontaneous Regression of Lung Metastases after Resection of CIC-Rearranged Sarcoma: A Case Report.

The vast majority of patients with soft tissue sarcomas (STS) of the trunk and bilateral lung metastases at diagnosis are considered incurable. These tumors have poor prognosis as only a palliative therapeutic approach can be offered to patients. We report on an extremely rare case in which bilateral lung metastases disappeared spontaneously following surgical resection of the primary CIC-rearranged sarcoma with no addition of chemotherapy or any other systemic therapy.

Structural bone allograft fractures in oncological procedures.

Purpose: We report our experience analysing the risk of fracture amongst allografts in limb-preserving surgery for bone tumours.

Methods: We retrospectively reviewed our experience with bone allograft and its major complications when used for limb -preserving operations for bone tumours. Forty-one structural allografts were performed in 39 patients between 1992 and 2012.

In vivo tricalcium phosphate, bone morphogenetic protein and autologous bone marrow biomechanical enhancement in vertebral fractures in a porcine model.

Purpose: Minimally invasive techniques that introduce cement and bone substitutes inside the fractured vertebral body are a new treatment line with clinically proven efficacy. However, mechanical behaviours between different fillers throughout fracture evolution is yet to be clarified, as many substances are available for introduction into the vertebral body fracture.

Methods: We comparatively studied biomechanical properties of tricalcium phosphate, tricalcium phosphate with bone morphogenetic protein (rhBMP-7) and autologous bone marrow aspirate with rhBMP-7 in vivo to determine what substance is optimal for repairing vertebral lesions in a porcine model.

Biomechanical assays for the study of the effects of hip prostheses: application to the reconstruction of bone defects with femoral allografts.

There is a need to study and validate the mechanical behavior of the bone-implant total hip prosthesis and the treatment of its complications with experimental studies due to the limitations showed by numerical methods. Epoxy resin replicas of a femur (stereolithography) and a mechanical validation were performed. We studied three cases: intact femur (Case 1); non-defective femur with non-cemented LD primary stem (Case 2); and femur with a cavitary defect, short cemented stem over an impacted allograft (Case 3).

Reconstruction of bone defects with impacted allograft in femoral stem revision surgery.

A retrospective clinical review was done on 54 revision hip patients. Radiological analysis examined the Gross and AAOS classifications, stem position, cement mantles, allograft and evolution (subsidence, resorption and remodelling). The Harris Hip score was used for clinical assessment.