Publications by authors named "Juan Lopez-Egido"
Article Synopsis
- The study investigates the role of BANK1 and BLK genes in systemic lupus erythematosus (SLE), highlighting their significance in B-cell signaling disruptions associated with the disease.
- Researchers employed various methods, including the GPAT16 technique and confocal microscopy, to explore gene interactions and the physical association between BANK1 and BLK.
- Findings revealed genetic interactions between these genes in a large patient cohort, confirming their protein-protein interaction, particularly upon B-cell activation, which sheds light on potential new pathways in understanding SLE and other autoimmune disorders.
Background: Apart from inactivation of the MEN1 gene, the molecular mechanisms involved in tumorigenesis of the endocrine organs and MEN1-associated non-endocrine lesions remain unknown.
Materials And Methods: In order to learn more about down-stream effects upon MEN1 gene inactivation BON1 cells were transfected with a MEN1 gene construct (BON/M1C), and both RT-differential display and oligonucleotide microarrays were performed.
Results: Three genes (SMARCC1, OVCA2 and SRp55) found to be differentially regulated on differential display were corroborated by northern blots on cell line RNA when comparing MEN1 transfected cells with control (empty vector transfection).
Recently the multiple endocrine neoplasia type 1 (MEN1) tumor suppressor gene was cloned. Its protein product, called menin, has been shown to associate with the AP1 transcription factor JunD and to repress JunD-mediated transcription. However, little is known concerning the regulation of menin.
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