D autoreceptor switches CB receptor effects on [ H]-dopamine release in the striatum.

CB receptors (CB R) are expressed in midbrain neurons. To evidence the control of dopamine release in dorsal striatum by CB R, we performed experiments of [ H]-dopamine release in dorsal striatal slices. We found a paradoxical increase in K -induced [ H]-dopamine release by CB R activation with GW 833972A and JWH 133 two selective agonist.