Publications by authors named "Juan Jose Alegre-Sancho"

Article Synopsis
  • The study aimed to see if adding oral glucocorticoids to immunosuppressive therapy improves skin conditions and safety in patients with early diffuse cutaneous systemic sclerosis (dcSSc).
  • It compared two groups: one receiving glucocorticoids combined with immunosuppression, and the other receiving only immunosuppression, assessing changes in the modified Rodnan skin score (mRSS) over about a year.
  • Results showed no significant difference in skin score improvement between the groups, indicating that low-dose glucocorticoids didn't provide added benefits for skin fibrosis nor raised the risk of scleroderma renal crisis.
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Article Synopsis
  • MSB11022 is a biosimilar to adalimumab that has shown comparable effectiveness and safety in patients with rheumatoid arthritis (RA) who switched from the reference adalimumab or another biosimilar.
  • *This study was a retrospective, multicenter analysis of 86 RA patients who maintained treatment with MSB11022 for at least 6 months, revealing high rates of disease remission and low activity.
  • *The results indicated that MSB11022 preserves the treatment benefits of adalimumab, with minimal adverse effects reported, consistent with existing safety profiles of other biosimilars.*
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VEXAS syndrome is a rare entity secondary to UBA1 gene mutations, located on the X chromosome. This mutation generates, as a consequence, a characteristic vacuolation on haematopoietic stem-cells. It is characterized by multiple autoinflammatory and haematologic manifestations, which respond and end up being dependent on corticosteroid treatment.

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Gluteal pain is a frequent cause of medical attention in the daily clinical practice. It can be caused by multiple pathologies, being ischiofemoral impingement syndrome among those included in its differential diagnosis. Encompassed within the deep gluteal syndromes, this entity occurs as a consequence of the entrapment of the neuromuscular structures between the lesser femoral trochanter and the ischial tuberosity, causing pain in the root of the lower limb, with irradiation towards the thigh or the gluteal region and poor tolerance to deambulation and sedestation.

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Introduction: Psoriatic arthritis (PsA) is a complex and heterogeneous inflammatory disease. Secukinumab, a biologic disease-modifying antirheumatic drug (bDMARD), has extensive clinical evidence of efficacy and safety in the treatment of PsA but data in clinical practice are still limited. This study aims to provide real-world evidence on secukinumab use, effectiveness, and persistence in PsA.

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Objective: The objective of this observational, descriptive, cross-sectional, multicentre study was to assess the perceived quality and grade of satisfaction expressed by patients with chronic arthropathies regarding the use of musculoskeletal (MSK) ultrasonography by rheumatologists as an integrated clinical care tool.

Methods: All Spanish rheumatology departments with MSK ultrasonography incorporated in their healthcare services were invited to participate in the study. A Spanish-language survey was offered to fill out anonymously to all consecutive patients with chronic arthropathies under follow-up in the rheumatology outpatient clinics who attended their centre for a period of 3 months.

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Lupus nephritis is a major cause of morbidity in patients with systemic lupus erythematosus. Responsiveness to treatment is crucial to avoid chronic kidney disease. New molecules have been developed in recent years to improve renal survival rates.

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Introduction: The knowledge of the aetiology of Behçet disease (BD), an immune-mediated vasculitis, is limited. HLA-B, mainly HLA-B51, and HLA-A molecules are associated with disease, but the ultimate cause of this association remains obscure. There is evidence that NK cells participate in the etiopathology of BD.

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Background: Secukinumab is a biologic disease-modifying antirheumatic drug (bDMARD) that has demonstrated efficacy in the treatment of axial spondyloarthritis (axSpA, i.e., ankylosing spondylitis and non-radiographic axSpA) across various clinical trials.

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Background: In patients with axial spondyloarthritis, vertebral fracture risk is elevated and not always correlated with bone mineral density (BMD). Trabecular bone score (TBS) may offer some advantages in the assessment of vertebral fracture risk in these patients. The primary objective of this study was to compare TBS and BMD between axial spondyloarthritis patients depending on their vertebral fracture status.

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Introduction: Psoriatic arthritis (PsA) is a chronic inflammatory disorder that primarily affects the joints and entheses. In addition, it is associated with depressive syndrome (DS), cardiovascular disease, hypertension (HT), diabetes mellitus (DM), obesity and psoriasis (Pso). There are few studies aimed to analyze the association of the involvement of the musculoskeletal system with sexual function (SF).

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Objective: To evaluate the effectiveness and safety of tocilizumab (TCZ) monotherapy in biologic-naïve patients with rheumatoid arthritis (RA) versus patients with previous biologic exposure in a real-world setting.

Materials And Methods: Non-controlled clinical-trial, 32-week prospective multicenter study including RA patients with moderate-severe disease activity starting TCZ in monotherapy who had a prior inadequate response or were intolerant to methotrexate (MTX). Effectiveness according to EULAR response evaluated at 24-week and safety at 32-weekwere assessed.

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Article Synopsis
  • Tocilizumab was investigated for its safety and effectiveness in improving skin and lung fibrosis in patients with systemic sclerosis (SSc) by analyzing data from the EUSTAR database.
  • The study compared 93 SSc patients treated with tocilizumab to 3180 patients receiving standard of care, measuring outcomes like skin scores and lung function over 12 months.
  • While no significant differences were found, the results leaned towards favoring tocilizumab, prompting further investigation into its potential effectiveness within a larger SSc population.
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  • The study focused on late skin fibrosis in systemic sclerosis (SSc), analyzing how it affects patients more than five years after the first non-Raynaud's disease symptoms.
  • Out of 1,043 patients examined, nearly 20% showed worsening skin conditions, indicating that late skin fibrosis is more prevalent than previously recognized.
  • Results suggest that lower baseline skin scores and certain antibodies influence the risk of late skin fibrosis, highlighting the need for more research and better treatment strategies in SSc management.
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  • The study examines cases of new or worsening psoriasis in patients receiving biological drugs, specifically focusing on chronic inflammatory diseases.
  • A total of 26 cases of paradoxical psoriasis were identified, with 93% of those patients treated with anti-TNFα drugs, notably adalimumab, which accounted for half of the occurrences.
  • The issue is generally reversible, but the chance of lesion recurrence increases if another anti-TNFα drug is reintroduced after discontinuation.
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Objective: Tofacitinib (TOF) is the first Janus kinase (JAK) inhibitor approved for psoriatic arthritis (PsA). It has shown efficacy in patients refractory to anti-tumor necrosis factor-α in randomized controlled trials (RCTs). Our aim was to assess efficacy and safety of TOF in clinical practice.

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Objectives: The study aim was to evaluate the estimated glomerular filtration rate (eGFR), its association with clinical disease and its predictive ability with respect to mortality in SSc patients from the European Scleroderma Trials and Research Group (EUSTAR) database.

Methods: SSc patients from the EUSTAR database who had items required for the calculation of eGFR at a baseline visit and a second follow-up visit available were included. A cut-off eGFR value of 60 ml/min was chosen for all SSc patients, and 30 ml/min for those with scleroderma renal crisis (SRC).

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Purpose: To investigate the role of plasma calprotectin in non-infectious uveitis.

Methods: This is an observational both cross-sectional and prospective study. Patients with active non-infectious uveitis were recruited as well as nonuveitic controls.

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Objective: To describe a multicentre case series of new onset or worsening of psoriasis in patients treated with biological drugs.

Material And Methods: Descriptive study. We reviewed the clinical history of patients with chronic inflammatory disease (CID) treated with biological drugs, who developed new onset or worsening of psoriasis during the follow-up period.

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