Study on the regulation of trophoblast activity by abnormally expressed hsa_circ_0024838/miR-543/HIF1A in patients with gestational diabetes mellitus.

Introduction: This study aimed to screen circRNAs involved in gestational diabetes mellitus (GDM)-related macrosomia. One differentially expressed circRNA (DEC), hsa_circ_0024838, was further tested for its potential role and mechanism in trophoblasts.

Methods: DECs in GDM were selected through GSE182737 and GSE194119.

Global evapotranspiration from high-elevation mountains has decreased significantly at a rate of 3.923 %/a over the last 22 years.

Clarifying the responses of human activities and climate change to the water cycle under variable environments is crucial for accurately assessing regional water balance. An analysis of the changes in actual evapotranspiration and its driving factors was conducted in the global high-elevation mountains during the period from 2001 to 2022. Utilizing 18 formulas for calculating evapotranspiration, which are based on comprehensive, temperature, radiation, and mass transfer, and then simulated the variations in reference evapotranspiration.

The effect of freeze-thaw action on the dynamic change of supra-permafrost water sources: A stable isotope perspective.

Due to the continuous degradation (gradual thawing) of permafrost, supra-permafrost water has become an important component of runoff that occurs in cold regions. However, current research has only focused on the amount of water provided by permafrost, and little has been reported regarding the source and formation mechanisms of supra-permafrost water. Due to the difficulty of observation and sampling in cold regions and insufficient data accumulation, model simulations face various difficulties in regard to solving problems related to hydrological processes.

Long-term organic amendments increase the vulnerability of microbial respiration to environmental changes: Evidence from field and laboratory studies.

Organic amendments can improve soil fertility and microbial diversity, making agroecosystems more resilient to stress. However, it is uncertain whether organic amendments will enhance the functional capacity of soil microbial communities, thereby mitigating fluctuations in microbial respiration caused by environmental changes. Here, we examined the impacts of long-term organic amendments on the dynamics of microbial catabolic capacity (characterized by enzyme activities and carbon source utilization) and microbial respiration, as well as their interrelationships during a period with fluctuating temperature and rainfall in the field.

Field investigation combined with modeling uncovers the ecological heterogeneity of Aedes albopictus habitats for strategically improving systematic management during urbanization.

Background: Aedes albopictus is an invasive vector of serious Aedes-borne diseases of global concern. Habitat management remains a critical factor for establishing a cost-effective systematic strategy for sustainable vector control. However, the community-based characteristics of Ae.

Particularity of hydrological processes under heavy ablation based on environmental isotopes in transition zones between endorheic and exorheic basins.

Drastic changes in the cryosphere have a significant impact on the quantity and formation process of water resources in the Qilian Mountains. The present study focused on quantitative evaluation of runoff components and runoff formation processes during strong ablation periods (August), in 2018, 2020, and 2021, in the transition zone between endorheic and exorheic basins in China, based on 1906 stable isotope samples. The results revealed that as the altitude decreased, the contribution of glacier and snow meltwater and permafrost water to runoff decreased, whereas that of the precipitation increased.

Comparison of clinical effects between early follicular prolonged GnRH agonist protocol and GnRH antagonist protocol in 3310 cycles: a retrospective study.

Background: It is the duty of doctors to choose a safe, simple, economic and effective controlled ovulation stimulation (COS) protocol for the patients. This study aims to compare the clinical effects of the early follicular prolonged GnRH agonist (EFPL) and GnRH antagonist (GnRH-Ant) protocols, hoping to provide some reference for clinicians when choosing COS program.

Methods: A retrospective study included 3310 ovum pick up cycles undergoing assisted reproductive technology during January 2019 to May 2022 in Renmin Hospital of Wuhan University.

Chromosomal analysis of 262 miscarried conceptuses: a retrospective study.

Background: Embryonic chromosomal abnormality is one of the significant causative factors of pregnancy loss. Our goal was to investigate the differences of chromosomal abnormality between different conception modes in miscarried products of conception (POCs).

Methods: A retrospective study included 262 miscarried POCs from 167 women undergoing assisted reproductive treatment (ART) and 95 spontaneous pregnant (SP) women during March 2019 to March 2022 in Renmin Hospital of Wuhan University.

A review of isotope ecohydrology in the cold regions of Western China.

The mountainous alpine area in western China is an Asian water tower and is an important ecological barrier area. Based on the previous research results, this study sorted out and summarized the isotopic ecohydrology of the alpine mountains in the western China and found that the local meteoric water line (LMWL) in the west of the alpine mountains is δD = 7.44δO + 5.

Environmental significance of atmospheric nitrogen deposition in the transition zone between the Tibetan Plateau and arid region.

The ecological effect of atmospheric N deposition has become a hot research point along with intensive human activities and global climatic change. As the transition zone between the Tibetan Plateau and the arid region, the Qilian Mountains are important ecological barriers and source regions of inland rivers in northwest China. However, the quantification of N deposition in the transition zone between the Tibetan Plateau (TP) and the arid region remains unclear, primarily due to the lack of in situ measurements.

The role of miRNA-339-5p in the function of vascular endothelial progenitor cells in patients with PCOS.

Research Question: miRNA-339 participates in diseases with endothelial progenitor cell (EPC) dysfunction. What is the role of miRNA-339-5p in EPC of polycystic ovary syndrome (PCOS)?

Design: Clinical data were collected from 76 controls and 84 PCOS patients. Noradrenaline, asymmetric dimethylarginine (ADMA), advanced glycation end products (AGE) and silent information regulator 1 (SIRT1) in the serum were measured.

Hydrochemical patterns indicating hydrological processes with the background of changing climatic and environmental conditions in China: a review.

In the background of global climate and environmental change, the hydrochemical characteristics of water bodies present significant instability to all regions, including humid, arid, and alpine ones. There are two main reasons for this: (1) climate change has altered the temporal and spatial distribution of precipitation, and climate warming intensified the mutual transformation of water bodies. The temperature in China increased by 0.

The high-risk factors of different severities of bronchopulmonary dysplasia (BPD) based on the national institute of child health and human development (NICHD) diagnosis criteria in 2018.

Objective: To investigate the clinical characteristics of preterm infants with different severities of bronchopulmonary dysplasia (BPD) and disclose the high-risk factors of exacerbating BPD.

Methods: Collection of clinical data of 91 preterm infants admitted to the NICU and diagnosed with BPD, categorized in groups according to the disease severity: 41 mild cases,, 24 moderate cases, and 26 severe cases. Comparison and analysis of perinatal risk factors, treatment, complications and prognosis of the infants with different severity degrees.

Physical growth and brain MRI predict the neurodevelopmental outcomes in very low birth weight infants at 2-year-old.

Objective: The purpose of the current study was to determine the predictive effect of physical growth and brain magnetic resonance imaging (MRI) on neurodevelopmental outcomes in very low birth weight infants (VLBW) infants.

Materials And Methods: A total of 85 VLBW infants were included in the current study. They were cared according to the guideline of preterm management during hospitalization, and to planned follow-up rules after discharged strictly.

High-throughput quantitation of trace level melatonin in human milk by on-line enrichment liquid chromatography-tandem mass spectrometry.

The level of melatonin in human milk might be closely related to infant development and the building up of their circadian rhythms. The large population investigation on this topic would provide insights for the prevention and treatment of diseases related to early development and circadian rhythms. However, it has not been well studied.

ICOS follicular regulatory T cells are implicated in the pathogenesis of ulcerative colitis.

Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) with a rising incidence worldwide. The precise aetiology is unclear, but aberrant regulatory T cell (Treg) responses have been documented in active UC patients. Follicular regulatory T cell (Tfr) is a recently identified subset of Treg cells.

[Urine metabolomics analysis based on ultra performance liquid chromatography-high resolution mass spectrometry combined with osmolality calibration sample concentration variability].

Urine is an important source of biomolecular information for metabolomic studies. However, the acquisition of high-quality metabolomic datasets or reliable biomarkers from urine is difficult owing to the large variations in the concentrations of endogenous metabolites in the biofluid, which are caused by diverse factors such as water consumption, drugs, and diseases. Thus, normalization or calibration is essential in urine metabolomics for eliminating such deviations.

The significance of an integrated management mode of prenatal diagnosis-postnatal treatment for critical congenital heart disease in newborns.

Background: Congenital heart disease (CHD) is the most common congenital defect in human beings. The purpose of this article is to investigate impact of an integrated management mode of 'prenatal diagnosis-postnatal treatment' on birth, surgery, prognosis and complications associated with critical CHD (CCHD) in newborns.

Methods: A retrospective analysis of the medical records of newborns diagnosed with CCHD were divided into two groups: prenatal diagnosis and postnatal diagnosis.

Environmental effect and spatiotemporal pattern of stable isotopes in precipitation on the transition zone between the Tibetan Plateau and arid region.

In the transition zone between the Tibetan Plateau and the arid region of northwestern China, the spatiotemporal patterns and environmental controls of stable isotopes in precipitation remain unclear. A network of 19 sampling stations was established across the Qilian Mountains to observe stable isotopes in precipitation, and 1310 precipitation event-scale samples were collected. The local meteoric water line (LMWL) was obtained and expressed as δD = 7.

Effect of perioperative amplitude-integrated electroencephalography on neurodevelopmental outcomes following infant heart surgery.

The purpose of the current study was to determine the effect of perioperative amplitude-integrated electroencephalography (aEEG) on neurodevelopmental outcomes in infants with congenital heart disease (CHD). A total of 93 children with CHD were included in the current study. All patients enrolled in the present study had undergone cardiac surgery prior to 3 months of age and pre- or postoperative aEEG was monitored.

Association between thyroid dysfunction and perinatal outcomes in women with gestational hypertension: a retrospective study.

Background: Previous studies showed that thyroid dysfunction in women with gestational hypertension could negatively affect maternal and fetal outcomes. In this study, we aimed to investigate whether thyroid dysfunction assessed in the second half trimester contributed to neonatal outcomes of pregnancy in different subtypes of gestational hypertension disease.

Methods: We performed a retrospective case-control study and collected data from 135 singleton pregnant women with gestational hypertension disease and their offspring who delivered in Renmin Hospital of Wuhan University from January 2015 to June 2017.

Peri- and Post-operative Amplitude-integrated Electroencephalography in Infants with Congenital Heart Disease.

Objective: To identify the factors influencing brain injury in infants with congenital heart disease (CHD) after cardiac surgery.

Methods: This retrospective study investigated 103 infants with CHD undergoing cardiac surgery between January 2013 and February 2016. Pre- and postoperative amplitude-integrated electroencephalography (aEEG) recordings were assessed for background pattern, sleep-wake cycle pattern and seizure activity.

[Genetic analysis of a case of chromosome 14q microdeletion].

Objective: To explore the genetic etiology of a child with autism, mental retardation and epilepsy.

Methods: Conventional G-banding chromosomal analysis was carried out. Chromosomal variation was also detected by single nucleotide polymorphism microarray (SNP array).