Publications by authors named "Juan Gonzalez-Del-Castillo"

Background And Importance: Elderly patients often have atypical clinical presentations. Lactate measurement on arrival at the Emergency Department (ED) could be useful to identify elderly patients with a bad prognosis.

Objective: The study aimed to investigate the relationship between serum lactate determined at ED arrival and the probability of inhospital mortality and intensive care (ICU) admission in elderly patients.

View Article and Find Full Text PDF
Article Synopsis
  • - The study analyzes the prevalence of benzodiazepine prescriptions among elderly patients visiting emergency departments in Spain and their impact on short-term health outcomes.
  • - Out of 25,557 patients studied, 30.8% were prescribed benzodiazepines, which were linked to an increased chance of returning to the emergency department but not to higher rates of hospitalization or mortality within 30 days.
  • - The findings suggest that while benzodiazepine use may lead to more frequent ED visits, it does not significantly affect hospitalization rates or mortality in the short term.
View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to investigate whether older patients (≥65 years) have a diminished tachypneic response to hypoxia, meaning they may not breathe faster in response to low oxygen levels as much as younger patients do.
  • Researchers analyzed data from 7126 patients in Spanish emergency departments, measuring peripheral arterial oxygen saturation (SatO2) and respiratory rate (RR) upon arrival, finding significant correlations across all age groups studied.
  • Results indicated that as patient age increased, the respiratory rate response to decreasing oxygen levels slowed down, with younger individuals showing a faster increase in breathing rate in response to hypoxia compared to older individuals, particularly those aged ≥90 years.
View Article and Find Full Text PDF

The prevalence of active hepatitis C virus (HCV) infection is higher in hospital emergency departments (EDs) than in the general population. Numerous patients who seek emergency care are unaware that they have detectable viremia, yet they fall outside established ED protocols for HCV screening. Often they belong to groups with difficult access to health care who use the ED as their point of entry to the system.

View Article and Find Full Text PDF

Objective: To study factors associated with hospitalization in an unselected population of patients aged 65 years or older treated for syncope in Spanish hospital emergency departments (EDs). To determine the prevalence of adverse events at 30 days in patients discharged home and the factors associated with such events.

Methods: We included all patients aged 65 years or older who were diagnosed with syncope during a single week in 52 Spanish EDs, recording patient clinical and ED case management data.

View Article and Find Full Text PDF
Article Synopsis
  • The study examines factors influencing whether older patients (≥65 years) are discharged home or admitted to the hospital after being treated in an emergency department observation unit (EDOU).
  • Data from 5,457 patients were analyzed, identifying five key indicators linked to a higher likelihood of discharge home, including the absence of fever and a Glasgow Coma Scale score of 15.
  • Although a prediction model was developed to assess discharge likelihood, it showed limited accuracy and highlighted the ongoing challenge of individual-level predictions for older patients.
View Article and Find Full Text PDF

Objective: Analyse the association between the use of diagnostic tests and the characteristics of older patients 65 years of age or more who consult the emergency department (ED).

Methods: We performed an analysis of the EDEN cohort that includes patients who consulted 52 Spanish EDs. The association of age, sex, and ageing characteristics with the use of diagnostic tests (blood tests, electrocardiogram (ECG), microbiological cultures, X-ray, computed tomography, ultrasound, invasive techniques) was studied.

View Article and Find Full Text PDF
Article Synopsis
  • A study evaluated the impact of older adults (aged 75+) spending a night in emergency departments (ED) on their risk of in-hospital mortality, comparing those who were admitted to wards before midnight versus those who stayed in the ED until morning.
  • Despite slightly higher in-hospital mortality rates for those in the ED (10.7%) compared to the ward group (9.5%), the differences were not statistically significant, indicating that staying overnight in the ED did not conclusively increase mortality risk.
  • The findings suggest that while older patients may face potential risks when waiting in an ED overnight, especially in non-academic hospitals, overall, there was no evidence of longer hospital stays or higher mortality rates tied to this practice
View Article and Find Full Text PDF

The elderly population frequently consults the emergency department (ED). This population could have greater use of EDs and hospital health resources. The EDEN cohort of patients aged 65 years or older visiting the ED allowed this association to be investigated.

View Article and Find Full Text PDF

COVID-19 continues to pose a significant threat: mortality stands at nearly twice that of influenza, and the incidence rate is growing as the population's vaccination rate decreases, particularly in Spain and other areas of Europe. Given this situation, it is vitally important know whether medical protocols are consistent and appropriately implemented by health care staff in the interest of preventing possible inefficiency or inequity. Physicians from hospital emergency departments met to study their hospitals' usual clinical practices for managing SARS-CoV-2 infection and to determine their expert opinions on the use of antiviral agents.

View Article and Find Full Text PDF

Objectives: To assess whether dementia is an independent predictor of death after a hospital emergency department (ED) visit by older adults with or without a COVID-19 diagnosis during the first pandemic wave.

Method: We used data from the EDEN-Covid (Emergency Department and Elderly Needs during Covid) cohort formed by all patients ≥65 years seen in 52 Spanish EDs from March 30 to April 5, 2020. The association of prior history of dementia with mortality at 30, 180 and 365 d was evaluated in the overall sample and according to a COVID-19 or non COVID diagnosis.

View Article and Find Full Text PDF

Objective: To describe other reasons for requesting HIV serology in emergency departments (ED) other than the 6 defined in the SEMES-GESIDA consensus document (DC-SEMES-GESIDA) and to analyze whether it would be efficient to include any of them in the future.

Methods: Review of all HIV serologies performed during 2 years in 20 Catalan EDs. Serologies requested for reasons not defined by the DC-SEMES-GESIDA were grouped by common conditions, the prevalence (IC95%) of seropositivity for each condition was calculated, and those whose 95% confidence lower limit was >0.

View Article and Find Full Text PDF
Article Synopsis
  • The study estimates pneumonia incidence in elderly patients in Spanish emergency departments, finding an annual rate of 18.4 cases per 1000 inhabitants.
  • A significant 78% of these patients required hospitalization, with 30-day mortality at 14.2% and in-hospital mortality at 12.9%.
  • Factors like functional dependency and severe comorbidity were closely linked to adverse events, while common biomarkers showed only moderate predictive ability for outcomes.
View Article and Find Full Text PDF

Background: Polypharmacy is a growing phenomenon among elderly individuals. However, there is little information about the frequency of polypharmacy among the elderly population treated in emergency departments (EDs) and its prognostic effect. This study aims to determine the prevalence and short-term prognostic effect of polypharmacy in elderly patients treated in EDs.

View Article and Find Full Text PDF

Objectives: To determine the value of the soluble urokinase-type plasminogen activator receptor (suPAR) for predicting outcomes in emergency department (ED) patients. Secondary objectives were 1) to measure the predictive value of the usual decision points, 2) to identify patients at low risk for mortality who could be safely discharged from the ED, and 3) to measure the correlation between suPAR and other biomarkers.

Material And Methods: Prospective observational cohort study of patients attended in the EDs of participating hospitals.

View Article and Find Full Text PDF

Objectives: To determine whether combining biomarkers of inflammatory response and clinical scales can improve risk stratification of patients with suspected infection in a hospital emergency department (ED).

Material And Methods: Prospective observational study of ED patients treated for infections. We collected the following information on arrival: demographic and baseline clinical data, comorbidities, the focus of infection, and values for the following inflammatory biomarkers: leukocyte counts, and C-reactive protein, procalcitonin, and midregional proadrenomedullin (MR-proADM) concentrations.

View Article and Find Full Text PDF

Objective: To analyze the prognostic accuracy of the scores NEWS, qSOFA, GYM used in hospital emergency department (ED) in the assessment of elderly patients who consult for an infectious disease.

Methods: Data from the EDEN (Emergency Department and Elderly Need) cohort were used. This retrospective cohort included all patients aged ≥65 years seen in 52 Spanish EDs during two weeks (from 1-4-2019 to 7-4-2019 and 30/3/2020 to 5/4/2020) with an infectious disease diagnosis in the emergency department.

View Article and Find Full Text PDF

Introduction: Mortality in emergency departments (EDs) is not well known. This study aimed to assess the impact of the first-wave pandemic on deaths accounted in the ED of older patients with COVID and non-COVID diseases.

Methods: We used data from the Emergency Department and Elderly Needs (EDEN) cohort (pre-COVID period) and from the EDEN-COVID cohort (COVID period) that included all patients ≥65 years seen in 52 Spanish EDs from April 1 to 7, 2019, and March 30 to April 5, 2020, respectively.

View Article and Find Full Text PDF

Objective: To develop a panel of indicators to monitor antimicrobial stewardship programs activity in the emergency department.

Methods: A multidisciplinary group consisting of experts in the management of infection in emergency departments and the implementation of antimicrobial stewardship programs (ASP) evaluated a proposal of indicators using a modified Delphi methodology. In the first round, each expert classified the relevance of each proposed indicators in two dimensions (healthcare impact and ease of implementation) and two attributes (prioritisation level and frequency).

View Article and Find Full Text PDF

Objectives: To determine whether income was associated with unexpected in-hospital mortality in older patients treated in Spanish public health system hospital emergency departments.

Material And Methods: Fifty-one public health system hospital emergency departments in Spain voluntarily participated in the study. Together the hospitals covered 25% of the population aged 65 years or older included in all patient registers during a week in the pre-pandemic period (April 1-7, 2019) and a week during the COVID-19 pandemic (March 30 to April 5, 2020).

View Article and Find Full Text PDF

Objectives: The aims of this study in the Emergency Department and Elder Needs (EDEN) series were to explore associations between clinical variables on arrival at the ED (baseline) and the insertion of a bladder catheter, and the relation between catheterization and deterioration to a more complex or serious clinical state.

Material And Methods: Included were all patients aged 65 years or older attended during 1 week in 52 Spanish EDs. Patients were grouped according to whether a bladder catheter was or was not inserted in the ED.

View Article and Find Full Text PDF

Background: While multidimensional and interdisciplinary assessment of older adult patients improves their short-term outcomes after evaluation in the emergency department (ED), this assessment is time-consuming and ill-suited for the busy environment. Thus, identifying patients who will benefit from this strategy is challenging. Therefore, this study aimed to identify older adult patients suitable for a different ED approach as well as independent variables associated with poor short-term clinical outcomes.

View Article and Find Full Text PDF