Emergence of New SARS-CoV2 Omicron Variants after the Change of Surveillance and Control Strategy.

Unlabelled: In January 2022, there was a global and rapid surge of the Omicron variant of SARS-CoV-2 related to more transmission. This coincided with an increase in the incidence in Asturias, a region where rapid diagnosis and containment measures had limited the circulation of variants.

Methods: From January to June 2022, 34,591 variants were determined by the SNP method.

Transcriptomic clustering of critically ill COVID-19 patients.

Background: Infections caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may cause a severe disease, termed coronavirus disease 2019 (COVID-19), with significant mortality. Host responses to this infection, mainly in terms of systemic inflammation, have emerged as key pathogenetic mechanisms and their modulation has shown a mortality benefit.

Methods: In a cohort of 56 critically ill COVID-19 patients, peripheral blood transcriptomes were obtained at admission to an intensive care unit (ICU) and clustered using an unsupervised algorithm.

Effects of IFIH1 rs1990760 variants on systemic inflammation and outcome in critically ill COVID-19 patients in an observational translational study.

Background: Variants in , a gene coding the cytoplasmatic RNA sensor MDA5, regulate the response to viral infections. We hypothesized that rs199076 variants would modulate host response and outcome after severe COVID-19.

Methods: Patients admitted to an intensive care unit (ICU) with confirmed COVID-19 were prospectively studied and rs1990760 variants determined.