Microwave imaging for breast cancer screening: protocol for an open, multicentric, interventional, prospective, non-randomised clinical investigation to evaluate cancer detection capabilities of MammoWave system on an asymptomatic population across multiple European countries.

Introduction: Microwave imaging presents several potential advantages including its non-ionising and harmless nature. This open, multicentric, interventional, prospective, non-randomised trial aims to validate MammoWave's artificial intelligence (AI)-based classification algorithm, leveraging microwave imaging, to achieve a sensitivity exceeding 75% and a specificity exceeding 90% in breast screening.

Methods And Analysis: 10 000 volunteers undergoing regular mammographic breast cancer screening will be recruited across 9 European centres and invited to participate in the clinical study, involving MammoWave testing on both breasts.

Gal3 Plays a Deleterious Role in a Mouse Model of Endotoxemia.

Lipopolysaccharide (LPS)-induced endotoxemia induces an acute systemic inflammatory response that mimics some important features of sepsis, the disease with the highest mortality rate worldwide. In this work, we have analyzed a murine model of endotoxemia based on a single intraperitoneal injection of 5 mg/kg of LPS. We took advantage of galectin-3 (Gal3) knockout mice and found that the absence of Gal3 decreased the mortality rate oflethal endotoxemia in the first 80 h after the administration of LPS, along with a reduction in the tissular damage in several organs measured by electron microscopy.

Vascular age in a sample of general population of the sanitary area of Toledo (Spain). RICARTO study.

Objective: To know the vascular age (VA) of a sample of general population included in the RICARTO study.

Patients And Method: Epidemiological study of the general population aged ≥18 from the Health Area of Toledo, based on the health card database. VA was calculated from the absolute cardiovascular risk (CVR) estimated with the Framingham and SCORE equations (type2 diabetes increased CVR in SCORE 2-fold in men and 4-fold in women).

TET2 Regulates the Neuroinflammatory Response in Microglia.

Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune cells. Despite the central role for microglia in neuroinflammation and neurodegeneration, little is known about their epigenomic regulation of the inflammatory response. Here, we show that Ten-eleven translocation 2 (TET2) methylcytosine dioxygenase expression is increased in microglia upon stimulation with various inflammogens through a NF-κB-dependent pathway.

Effects of repeated yearly exposure to exercise-training on blood pressure and metabolic syndrome evolution.

Objective: To study if repeated yearly training programs consolidate the transient blood pressure (BP) improvements of one exercise program into durable adaptations.

Methods: Obese middle-age individuals with metabolic syndrome (MetS) underwent high-intensity aerobic interval training during 16 weeks (November to mid-March) in 3 consecutive years [training group (TRAIN); N = 23]. Evolution of MetS components was compared with a matched-group that remained sedentary [control group (CONT); N = 26].

[Breakfasting with experts: quality and innovation].

The 26th Congress of the Spanish Society for Healthcare Quality was held in the city of Saragossa, Spain, in October 2008. The Scientific Committee introduced a new session format, called "breakfasting with experts". The aim was to create a relaxed atmosphere, in which participants and experts could debate several matters.

[Quality control program in a group of Spanish public hospitals (1993-2001)].

Introduction: The INSALUD (National Healthcare Institute) is a public institution that manages the provision of health services for 15 million Spanish people. INSALUD developed a quality control program for specialist care, which involved its 80 hospitals.

Objectives Of The Program: To promote leadership among the managers of quality assurance programs, to involve in the improvement of quality all the employees of the organization and to set out the Institution's following strategic outlines: to direct the services towards the needs of the population, to improve the quality and effectiveness of the care procedures, to minimize risks and to improve the information system.