Predictors of adverse effects to antiseizure drugs in adult patients with epilepsy from Colombia: A case-control study.

Introduction: Adverse drug reactions (ADRs) to antiseizure therapy can worsen the quality of life, reduce adherence, and potentially lead to treatment discontinuation and uncontrolled seizures.

Objectives: The aim of the study was to develop a prognostic model for ADRs to antiseizure therapy in adult patients with epilepsy from Colombia.

Methods: This case-control study included adult patients with epilepsy, who were separated into two groups: one group with ADRs to antiseizure therapy (cases), as determined by a complete evaluation conducted by an epileptologist, and another group without ADRs (controls).

Multivariable prediction model of drug resistance in adult patients with generalized epilepsy from Colombia: A case-control study.

Introduction: Patients with drug-resistant epilepsy (DRE) account for most of the burden of epilepsy, and they have poor prognosis in seizure control, higher morbidity, and mortality.

Objectives: The objective of the study was to develop a prognostic model of drug resistance in adult patients with generalized epilepsy from Colombia.

Methods: In this case-control study of patients with generalized epilepsy, patients were separated into two groups: one group with DRE (cases) according to the new International League Against Epilepsy (ILAE) definition after a complete evaluation performed by an epileptologist and the other group without DRE (control).