Publications by authors named "Juan F Toscano"
Article Synopsis
- Vein of Galen malformations (VGMs) are serious congenital issues that need multiple endovascular treatments due to high blood flow and related complications like heart failure and hydrocephalus.
- An 8-month-old with VGM showed heart failure symptoms and was treated using a transvenous approach for coil embolization while continuously monitoring venous pressures to assess treatment effectiveness.
- The successful monitoring revealed increasing pressure gradients correlating with improved blood flow reduction, leading to better patient outcomes post-surgery, suggesting a new method for objectively guiding VGM treatment.
Background: Intracranial atherosclerotic disease (ICAD) is one of the leading causes of stroke worldwide. Patients with ICAD who initially present with ischemia in border-zone areas and undergo intensive medical management (IMM) have the highest recurrence rates (37% at 1 yr) because of association with hemodynamic failure and poor collaterals.
Objective: To evaluate the effect of encephaloduroarteriosynagiosis (EDAS) on stroke recurrence in patients with ICAD and border-zone stroke (BDZS) at presentation.
Background: Intracranial atherosclerotic disease (ICAD) is one of the most challenging stroke etiologies, with frequent recurrences despite optimized medical management. Encephaloduroarteriosynangiosis (EDAS) is an indirect revascularization method that produces extra-cranial collaterals to intracranial vessels. We present the results of a phase-II trial of EDAS in intracranial atherosclerotic disease patients.
View Article and Find Full Text PDFIntracranial atherosclerotic disease (ICAD) is a common cause of stroke with high rates of ischemic recurrence. We aimed to investigate the role of circulating exosomal microRNAs (e-miRNAs) in recurrent ischemic events in ICAD. Consecutive patients with severe ICAD undergoing intensive medical management (IMM) were prospectively enrolled.
View Article and Find Full Text PDFBackground: Vascular endothelial growth factor-A (VEGF-A) has been identified as a combination of 2 alternative splice variants: proangiogenic VEGF-Aa and antiangiogenic VEGF-Ab. Intracranial atherosclerotic disease (ICAD) and moyamoya disease (MMD) are 2 main types of intracranial arterial steno-occlusive disorders with distinct capacities for collateral formation. Recent studies indicate that VEGF-A regulates collateral growth in ischemia.
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