Publications by authors named "Juan F Cubillos"
Article Synopsis
- Aging significantly decreases the ability of oligodendrocyte progenitor cells (OPCs) to grow and develop, but increasing the expression of the protein c-Myc can reverse this decline.
- c-Myc not only rejuvenates aged OPCs but also induces an aged-like state in younger OPCs when its expression is inhibited, indicating its crucial role in determining cell age.
- Enhancing c-Myc levels in aged OPCs in a living organism can restore their regenerative abilities, which could have important implications for understanding how stem cells function as they age and how to improve regeneration in older individuals.
Following central nervous system (CNS) demyelination, adult oligodendrocyte progenitor cells (OPCs) can differentiate into new myelin-forming oligodendrocytes in a regenerative process called remyelination. Although remyelination is very efficient in young adults, its efficiency declines progressively with ageing. Here we performed proteomic analysis of OPCs freshly isolated from the brains of neonate, young and aged female rats.
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