Aging and putative frailty biomarkers are altered by spaceflight.

Human space exploration poses inherent risks to astronauts' health, leading to molecular changes that can significantly impact their well-being. These alterations encompass genomic instability, mitochondrial dysfunction, increased inflammation, homeostatic dysregulation, and various epigenomic changes. Remarkably, these changes bear similarities to those observed during the aging process on Earth.

A second space age spanning omics, platforms and medicine across orbits.

The recent acceleration of commercial, private and multi-national spaceflight has created an unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number of crewed missions entering space and preparations for exploration-class (lasting longer than one year) missions. Such rapid advancement into space from many new companies, countries and space-related entities has enabled a 'second space age'. This era is also poised to leverage, for the first time, modern tools and methods of molecular biology and precision medicine, thus enabling precision aerospace medicine for the crews.

Absorption Properties of Microgel-PVP Composite Nanofibers Made by Electrospinning.

The absorption and desorption of water, as well as the retention of certain molecules within a polymeric network, have special interest in a wide range of applications, including drug delivery, biosensing, chemical separation, catalysis, and optics. In this communication, we report the encapsulation by electrospinning of poly(N-isopropylacrylamide)-based monodisperse microgels within microfibers of crosslinked poly(vinylpyrrolidone), which is a hydrogel itself, up to concentrations of 40 wt.-% of the microgels.