Publications by authors named "Juan Diego Unciti"
Preclinical Investigation in Neuroprotective Effects of the GPR55 Ligand VCE-006.1 in Experimental Models of Parkinson's Disease and Amyotrophic Lateral Sclerosis.
Sonia Burgaz Concepción García Claudia Gonzalo-Consuegra Marta Gómez-Almería Francisco Ruiz-Pino Juan Diego Unciti
Molecules
December 2021
Article Synopsis
- Cannabinoids, especially through CB receptors and GPR55, have shown neuroprotective effects in preclinical models of neurodegenerative diseases, sparking significant research interest.
- The study tested a compound called VCE-006.1, which acts on GPR55, and found it effective in reversing motor defects and neuron loss in models of Parkinson's disease, although it had limited effects on inflammatory reactions.
- Despite showing some protective benefits in models of neurodegeneration, the compound did not alter GPR55 expression levels, potentially explaining its varied effectiveness in different experimental setups.